O-1918

O-1918是一种人工合成的有机化合物，分子式C₁₉H₂₆O₂，化学结构上与大麻二酚相似，可作为前孤儿受体G蛋白偶联受体GPR18和GPR55的受体拮抗剂。^{[1][2][3][4][5]}

O-1918

识别信息
IUPAC命名法 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene
CAS号	536697-79-7  Y
PubChem CID	40469923
UNII	2DGR9Z5BT3
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID10610371
化学信息
化学式	C19H26O2
摩尔质量	286.19
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES CC1=C[C@@H](C2=C(OC)C=C(C)C=C2OC)[C@H](C(C)=C)CC1

参考文献

1. Offertáler L, Mo FM, Bátkai S, et al. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Molecular Pharmacology. March 2003, 63 (3): 699–705. PMID 12606780. doi:10.1124/mol.63.3.699.
2. Zakrzeska A, Schlicker E, Baranowska M, et al. A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats. British Journal of Pharmacology. June 2010, 160 (3): 574–84. PMC 2931558 . PMID 20105178. doi:10.1111/j.1476-5381.2009.00579.x.
3. Schuelert N, McDougall JJ. The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. Neuroscience Letters. August 2011, 500 (1): 72–6. PMID 21683763. S2CID 3410391. doi:10.1016/j.neulet.2011.06.004.
4. Szczesniak AM, Maor Y, Robertson H, et al. Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure. Journal of Ocular Pharmacology and Therapeutics. October 2011, 27 (5): 427–35. PMID 21770780. doi:10.1089/jop.2011.0041.
5. Caldwell MD, Hu SS, Viswanathan S, et al. A GPR18-based signalling system regulates IOP in murine eye. British Journal of Pharmacology. June 2013, 169 (4): 834–43. PMC 3687663 . PMID 23461720. doi:10.1111/bph.12136.

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