HIST4H4

HIST4H4为人体中的一种编码一类组蛋白H4的基因^[5]。HIST4H4没有内含子，编码组蛋白H4家族中的一种蛋白质。HIST4H4基因对应的mRNA缺乏Poly(A)尾巴。不过，这类mRNA有一个回文终止元件^[6]。

HIST4H4
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4H9O、​3WKJ、​3AYW、​3WA9、​5B0Z、​5AVB、​2CV5、​5AV5、​3AV2、​3WTP、​3AV1、​3AZK、​3X1V、​5AV8、​1F66、​4QUU、​3CFS、​4YYK、​4QUT、​3NQJ、​3A6N、​3W99、​5AVC、​2RS9、​3F9Z、​3QZT、​3QBY、​3W97、​4M38、​4YM6、​3CFV、​4HGA、​1EQZ、​2RJE、​3QZV、​1HQ3、​4H9P、​3AZL、​3AFA、​1TZY、​3UVY、​5CPK、​3JPX、​4U9W、​4N3W、​4YYJ、​4YYD、​4H9N、​4H9R、​3AZI、​4LD9、​3UVX、​3AZH、​5BNX、​4N4F、​1U35、​4YYG、​3O36、​2ARO、​5AV9、​4H9S、​3AZF、​3W98、​4GQB、​4H9Q、​5BNV、​3WAA、​3AZG、​3AZE、​2RNY、​1ZKK、​2QQS、​2LVM、​3X1T、​3AN2、​2KWO、​3QZS、​3F9W、​5FFW、​5CPJ、​3F9X、​3IJ1、​4YM5、​3AZJ、​4YY6、​3AZN、​2IG0、​4YYH、​4YYI、​5CPI、​3W96、​3R45、​2KWN、​3F9Y、​5AV6、​3AZM、​5BO0、​3X1S、​4QYD、​4KGC、​3UVW、​4YYN、​3X1U、​3UW9、​2F8N、​3NQU、​5B0Y、​4YYM、​5C3I、​4Z5T、​5B24、​5FA5、​4Z2M、​5E5A、​5FWE、​5B2I、​5B40、​5B2J、​5JA4、​5AY8、​4ZUX
识别号
别名	H4-16；, H4/p, histone cluster 4, H4, histone cluster 4 H4, HIST4H4, H4 histone 16, H4C5, H4C4, H4C9, H4C12, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2, H4C16
外部ID	OMIM：615069 MGI：2448432 HomoloGene：134468 GeneCards：H4-16
基因位置（人类） 染色体 12号染色体[1] 基因座 12p12.3 起始 14,767,999 bp[1] 终止 14,771,131 bp[1]
基因位置（小鼠） 染色体 小鼠13号染色体[2] 基因座 13|13 A3.1 起始 22,224,806 bp[2] 终止 22,225,532 bp[2]
基因本体 分子功能 • protein domain specific binding • 血浆蛋白结合 • protein heterodimerization activity • DNA结合 • histone binding • RNA binding 细胞组分 • 膜 • 染色体 • 核质 • 细胞外区域 • nuclear chromosome • 核小体 • 外排体 • 细胞核 • 细胞外间质 • 大分子复合体 生物学过程 • telomere organization • epigenetic maintenance of chromatin in transcription-competent conformation • protein heterotetramerization • negative regulation of megakaryocyte differentiation • CENP-A containing chromatin assembly • DNA replication-dependent chromatin assembly • rDNA heterochromatin assembly • negative regulation of gene expression, epigenetic • DNA-templated transcription, initiation • double-strand break repair via nonhomologous end joining • beta-catenin-TCF complex assembly • telomere capping • nucleosome assembly • regulation of gene silencing by miRNA • regulation of megakaryocyte differentiation • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	121504	319158
Ensembl	ENSG00000197837	ENSMUSG00000060639
UniProt	P62805	P62806
mRNA​序列	NM_175054	NM_175656
蛋白序列	NP_003537 ​NP_003486 ​NP_003535 ​NP_003539 ​NP_003531 ​NP_003536	NP_291074 ​NP_783587 ​NP_783588 ​NP_835499 ​NP_835500 ​NP_001182350 ​NP_835515 ​NP_783585 ​NP_783586 ​NP_835582 ​NP_835583 ​NP_783583 ​NP_694813
基因位置​（UCSC）	Chr 12: 14.77 – 14.77 Mb	Chr 13: 22.22 – 22.23 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

参考

1. GRCh38: Ensembl release 89: ENSG00000197837 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060639 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ. The human and mouse replication-dependent histone genes. Genomics. Oct 2002, 80 (5): 487–98. PMID 12408966. doi:10.1016/S0888-7543(02)96850-3.
6. Entrez Gene: HIST4H4 histone cluster 4, H4. （原始内容存档于2019-10-17）.

拓展阅读

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