C-Myc

C-Myc或Myc是编码转录因子的调节基因。这一基因编码的蛋白在细胞核内被磷酸化，有多种功能：在细胞周期进程、细胞凋亡和细胞转化中发挥作用。^[5]

c-Myc
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1A93、​1EE4、​1MV0、​1NKP、​2A93、​2OR9、​4Y7R
识别号
别名	MYC；, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc
外部ID	OMIM：190080 MGI：97250 HomoloGene：31092 GeneCards：MYC
基因位置（人类） 染色体 8号染色体[1] 基因座 8q24.21 起始 127,735,434 bp[1] 终止 127,742,951 bp[1]
基因位置（小鼠） 染色体 小鼠15号染色体[2] 基因座 15 D1|15 26.19 cM 起始 61,857,240 bp[2] 终止 61,862,223 bp[2]
基因本体 分子功能 • DNA结合 • protein dimerization activity • DNA结合转录因子活性 • DNA-binding transcription activator activity, RNA polymerase II-specific • 转录因子结合 • RNA polymerase II cis-regulatory region sequence-specific DNA binding • E-box binding • 血浆蛋白结合 • 大分子复合物结合 • DNA-binding transcription factor activity, RNA polymerase II-specific • DNA结合转录阻遏物活性，RNA聚合酶II特异性 细胞组分 • 核质 • 核仁 • 细胞核 • 大分子复合体 生物学过程 • Notch信号通路 • 染色体重建 • negative regulation of monocyte differentiation • positive regulation of metanephric cap mesenchymal cell proliferation • regulation of transcription, DNA-templated • regulation of telomere maintenance • positive regulation of epithelial cell proliferation • positive regulation of fibroblast proliferation • cellular response to UV • oxygen transport • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • chromosome organization • MAPK cascade • cellular response to DNA damage stimulus • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • branching involved in ureteric bud morphogenesis • negative regulation of cell division • fibroblast apoptotic process • positive regulation of mesenchymal cell proliferation • positive regulation of response to DNA damage stimulus • positive regulation of cell population proliferation • positive regulation of DNA biosynthetic process • 基因调节 • canonical Wnt signaling pathway • negative regulation of stress-activated MAPK cascade • energy reserve metabolic process • response to growth factor • response to gamma radiation • negative regulation of fibroblast proliferation • positive regulation of transcription by RNA polymerase II • cellular iron ion homeostasis • beta-catenin-TCF complex assembly • transcription, DNA-templated • transcription by RNA polymerase II • regulation of transcription by RNA polymerase II • protein deubiquitination • positive regulation of transcription, DNA-templated • positive regulation of telomerase activity • positive regulation of gene expression • protein-DNA complex disassembly • ERK1 and ERK2 cascade • cellular response to hypoxia • G1/S transition of mitotic cell cycle • cytokine-mediated signaling pathway • positive regulation of DNA methylation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	4609	17869
Ensembl	ENSG00000136997	ENSMUSG00000022346
UniProt	P01106	P01108
mRNA​序列	NM_002467 ​NM_001354870	NM_001177352 ​NM_001177353 ​NM_001177354 ​NM_010849
蛋白序列	NP_002458 ​NP_001341799	NP_001170823 ​NP_001170824 ​NP_001170825 ​NP_034979
基因位置​（UCSC）	Chr 8: 127.74 – 127.74 Mb	Chr 15: 61.86 – 61.86 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

相互作用

Myc可与以下蛋白质发生交互作用：

• ACTL6A^[6]
• BRCA1^{[7][8][9][10]}
• Bcl-2^[11]
• Cyclin T1^[12]
• CHD8^[13]
• DNMT3A^[14]
• EP400^[15]
• GTF2I^[16]
• HTATIP^[17]
• let-7^[18][19][20]
• MAPK1^[11][21][22]
• MAPK8^[23]
• MAX^{[24][25][26][27][28][29][30][31][32][33][34][35][36]}
• MLH1^[28]
• MYCBP2^[37]
• MYCBP^[38]
• NMI^[7]
• NFYB^[39]
• NFYC^[40]
• P73^[41]
• PCAF^[42]
• PFDN5^[43][44]
• RuvB-like 1^[6][15]
• SAP130^[42]
• SMAD2^[45]
• SMAD3^[45]
• SMARCA4^[6][24]
• SMARCB1^[27]
• SUPT3H^[42]
• TIAM1^[46]
• TADA2L^[42]
• TAF9^[42]
• TBX3^[47]
• TFAP2A^[48]
• TRRAP^{[6][25][26][42]}
• WDR5^[49]
• YY1^[50]

• ZBTB17.^[51][52]

参考文献

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2. GRCm38: Ensembl release 89: ENSMUSG00000022346 - Ensembl, May 2017
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