胸腺基质淋巴细胞生成素

胸腺基质淋巴细胞生成素（英语：Thymic stromal lymphopoietin，缩写TSLP）是一种由人类基因 TSLP 编码的蛋白质，是与白细胞介素-2类似的细胞因子^[6][7]，其受体α亚基与白细胞介素-7共用，β亚基由CRLF2基因编码^[8]。

胸腺基质淋巴细胞生成素
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4NN5、​4NN6、​4NN7
识别号
别名	TSLP；, thymic stromal lymphopoietin
外部ID	OMIM：607003 MGI：1855696 HomoloGene：81957 GeneCards：TSLP
相关疾病
过敏性鼻炎[1]
基因位置（人类） 染色体 5号染色体[2] 基因座 5q22.1 起始 111,070,062 bp[2] 终止 111,078,026 bp[2]
基因位置（小鼠） 染色体 小鼠18号染色体[3] 基因座 18 B1|18 18.12 cM 起始 32,948,436 bp[3] 终止 32,952,850 bp[3]
基因本体 分子功能 • 细胞因子活性 • interleukin-7 receptor binding 细胞组分 • 细胞外空间 • 细胞外区域 生物学过程 • regulation of signaling receptor activity • interleukin-7-mediated signaling pathway • positive regulation of cytokine-mediated signaling pathway • positive regulation of cell population proliferation • positive regulation of chemokine production • positive regulation of interleukin-10 production • positive regulation of interleukin-13 production • positive regulation of interleukin-5 production • positive regulation of interleukin-6 production • positive regulation of mast cell activation • positive regulation of tyrosine phosphorylation of STAT protein • negative regulation of apoptotic process • positive regulation of inflammatory response • defense response to Gram-negative bacterium • defense response to fungus • antimicrobial humoral immune response mediated by antimicrobial peptide • positive regulation of chemokine (C-C motif) ligand 1 production • positive regulation of granulocyte colony-stimulating factor production • positive regulation of receptor signaling pathway via STAT Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	85480	53603
Ensembl	ENSG00000145777	ENSMUSG00000024379
UniProt	Q969D9	Q9JIE6
mRNA​序列	​NM_033035 ​NM_138551	NM_021367
蛋白序列	NP_149024 ​NP_612561	NP_067342
基因位置​（UCSC）	Chr 5: 111.07 – 111.08 Mb	Chr 18: 32.95 – 32.95 Mb
PubMed​查找	[4]	[5]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. 與胸腺基质淋巴细胞生成素相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000145777 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000024379 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Ebina-Shibuya R, Leonard WJ. Role of thymic stromal lymphopoietin in allergy and beyond. Nature Reviews. Immunology. January 2023, 23 (1): 24–37. PMC 9157039 . PMID 35650271. doi:10.1038/s41577-022-00735-y.
7. Tsilingiri K, Fornasa G, Rescigno M. Thymic Stromal Lymphopoietin: To Cut a Long Story Short. Cellular and Molecular Gastroenterology and Hepatology. March 2017, 3 (2): 174–182. PMC 5331833 . PMID 28275684. doi:10.1016/j.jcmgh.2017.01.005.
8. Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF. Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. American Journal of Respiratory Cell and Molecular Biology. August 2016, 55 (2): 264–274. PMC 4979369 . PMID 26934097. doi:10.1165/rcmb.2015-0380OC.

外部链接

• PDB中UniProt可用的所有结构信息之概述：Q969D9 (Thymic stromal lymphopoietin) 在PDBe-KB（英语：PDBe-KB）。