前259年，提马克斯和托勒密发动叛乱对抗托勒密埃及托勒密二世。隔年，塞琉古帝国安条克二世因第二次叙利亚战争进攻托勒密属地米利都，提马克斯被杀。米利都市民欢天喜地，给解放城市的安条克二世“神”的称号。
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