徐机开始在东晋为郎中,苏峻反,顾众派遣徐机联络蔡谟。后来徐机归顺冉闵,冉魏永兴元年(350年,晋穆帝永和六年),冉闵代后赵建魏称帝,任徐机为尚书令,主理朝政。永兴二年(351年,晋穆帝永和七年),冉闵率军攻打后赵的残余势力石祗,在襄国大战。冉魏军大败,石祗杀死司空石璞、尚书令徐机、中书监卢谌等,死亡的人总共达十多万。永兴三年(352年,晋穆帝永和八年),冉魏亡于前燕。
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