PER2

PER2是由人类基因per2 编码的蛋白质，与昼夜节律有关^[6][7]，是黑腹果蝇 Period 基因在哺乳动物基因组中的同源物^[8]。

PER2
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 3GDI、​4CT0、​4U8H
识别号
别名	PER2；, FASPS, FASPS1, period circadian clock 2, period circadian regulator 2
外部ID	OMIM：603426 MGI：1195265 HomoloGene：7885 GeneCards：PER2
相关疾病
advanced sleep phase syndrome[1]
基因位置（人类） 染色体 2号染色体[2] 基因座 2q37.3 起始 238,244,044 bp[2] 终止 238,290,102 bp[2]
基因位置（小鼠） 染色体 小鼠1号染色体[3] 基因座 1|1 D 起始 91,343,704 bp[3] 终止 91,387,046 bp[3]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • 转录共激活因子活性 • transcription cis-regulatory region binding • 血浆蛋白结合 • transcription corepressor binding • 转录因子结合 细胞组分 • 核仁 • 细胞质的核周区域 • 细胞核 • 细胞质 生物学过程 • histone H3 deacetylation • 糖异生 • regulation of transcription, DNA-templated • regulation of insulin secretion • rhythmic process • negative regulation of fat cell proliferation • negative regulation of circadian rhythm • negative regulation of transcription by RNA polymerase II • circadian regulation of gene expression • transcription, DNA-templated • 脂肪酸代谢 • regulation of cell cycle • negative regulation of protein ubiquitination • circadian regulation of translation • response to ischemia • regulation of vasoconstriction • glycogen biosynthetic process • negative regulation of transcription regulatory region DNA binding • regulation of circadian rhythm • 昼夜节律 • white fat cell differentiation • regulation of glutamate uptake involved in transmission of nerve impulse • lactate biosynthetic process • negative regulation of transcription, DNA-templated • regulation of neurogenesis • positive regulation of nucleic acid-templated transcription • response to light stimulus • entrainment of circadian clock by photoperiod • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	8864	18627
Ensembl	ENSG00000132326	ENSMUSG00000055866
UniProt	O15055	O54943
mRNA​序列	​NM_003894 ​NM_022817	NM_011066
蛋白序列	NP_073728	NP_035196
基因位置​（UCSC）	Chr 2: 238.24 – 238.29 Mb	Chr 1: 91.34 – 91.39 Mb
PubMed​查找	[4]	[5]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. 與PER2相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000132326 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000055866 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–9. PMID 9427249. S2CID 10059149. doi:10.1016/S0896-6273(00)80417-1 .
7. Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptácek LJ. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. Jan 2007, 128 (1): 59–70. PMC 1828903 . PMID 17218255. doi:10.1016/j.cell.2006.11.043.
8. Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF, Reppert SM. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. Dec 1997, 19 (6): 1261–1269. PMID 9427249. S2CID 10059149. doi:10.1016/s0896-6273(00)80417-1 .

外部链接

• 医学主题词表（MeSH）：PER2+protein,+human
• PDB中UniProt可用的所有结构信息之概述：O15055 (Human Period circadian protein homolog 2) 在PDBe-KB（英语：PDBe-KB）。
• PDB中UniProt可用的所有结构信息之概述：O54943 (Mouse Period circadian protein homolog 2) 在PDBe-KB（英语：PDBe-KB）。