ERG11或甾醇-14-去甲基酶(Sterol 14-demethylase)是一种真菌细胞色素P450酶,最初发现于酿酒酵母(Saccharomyces cerevisiae)基因组,属于CYP51家族,代号CYP51F1[1]。ERG11催化羊毛甾醇转化为酵母甾醇的第一步,羊毛甾醇的14α-去甲基化生成4,4-二甲基-5α-胆甾-8(9),14,24-三烯-3β-醇,酵母甾醇会进一步生成麦角固醇[2]。
Sterol 14-demethylase | |
---|---|
标识 | |
生物 | |
符号 | ERG11 |
可选符号 | CYP51F1 |
Entrez | 856398 |
RefSeq (mRNA) | NM_001179137 |
RefSeq (蛋白质) | NP_011871 |
UniProt | P10614 |
其他数据 | |
EC number | 1.14.14.154 |
染色体 | VIII: 0.12 - 0.12 Mb |
参考文献
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