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去甲肾上腺素转运体
位於16號人類染色體的基因 / 维基百科,自由的 encyclopedia
去甲肾上腺素转运体(英语:Norepinephrine_transporter,NET),也被称为溶质载体家族6成员2(英语:solute carrier family 6 member 2,SLC6A2),是由SLC6A2基因编码的蛋白质。[6]。NET是一种单胺转运体(英语:monoamine transporter),负责依赖Na+/Cl−的胞外去甲肾上腺素再摄取。NET也可转运多巴胺。对这两种神经递质的再吸收是调控突触间隙(英语:synaptic cleft)传导物浓度的重要机制。
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NET以及其他单胺转运体是不少抗抑郁剂以及娱乐性药物的作用对象。过少的NET跟直立不耐症(英语:orthostatic intolerance)相关,过多NET则和ADHD相关。[7][8]
参见
- 神经递质转运体(英语:Neurotransmitter transporter)
- Sodium:neurotransmitter symporter(英语:Sodium:neurotransmitter symporter)
- 溶质载体家族(英语:Solute carrier family)
- 去甲肾上腺素
- 单胺转运体(英语:Monoamine transporter)
- 直立不耐症(英语:Orthostatic intolerance)
- 单核苷酸多态性
参考资料
- Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0.
- Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3.
- Tellioglu T, Robertson D. Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications. Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878.
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