LAMA1

层粘连蛋白亚基α1是一个层粘连蛋白的蛋白亚基。层粘蛋白是一种组成核纤层的蛋白，在细胞核的形态维持中扮演重要角色。此蛋白质在人体内由LAMA1基因编码^[7][8]。

LAMA1
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 2JD4
识别号
别名	LAMA1；, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1
外部ID	OMIM：150320 MGI：99892 HomoloGene：21146 GeneCards：LAMA1
相关疾病
2型糖尿病、​ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome[1]
为以下药物的标靶
ocriplasmin[2]
基因位置（人类） 染色体 18号染色体[3] 基因座 18p11.31 起始 6,941,742 bp[3] 终止 7,117,797 bp[3]
基因位置（小鼠） 染色体 小鼠17号染色体[4] 基因座 17 E1.1|17 38.8 cM 起始 68,004,254 bp[4] 终止 68,129,642 bp[4]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • signaling receptor binding • extracellular matrix structural constituent • 血浆蛋白结合 • protein C-terminus binding • glycosphingolipid binding 细胞组分 • 细胞外间质 • 细胞外区域 • 基底膜 • laminin-1 complex • laminin-3 complex • 细胞外空间 • 膜 • cell-cell junction • laminin complex • collagen-containing extracellular matrix 生物学过程 • cell surface receptor signaling pathway • regulation of cell adhesion • 细胞粘附 • extracellular matrix organization • regulation of cell migration • regulation of embryonic development • morphogenesis of an epithelial sheet • protein phosphorylation • 组织发生 • neuron projection development • establishment of epithelial cell apical/basal polarity • retina development in camera-type eye • epithelial tube branching involved in lung morphogenesis • branching involved in salivary gland morphogenesis • retinal blood vessel morphogenesis • 轴突导向 • animal organ morphogenesis • camera-type eye development • blood vessel morphogenesis Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	284217	16772
Ensembl	ENSG00000101680	ENSMUSG00000032796
UniProt	P25391	P19137
mRNA​序列	NM_005559	NM_008480
蛋白序列	NP_005550	NP_032506
基因位置​（UCSC）	Chr 18: 6.94 – 7.12 Mb	Chr 17: 68 – 68.13 Mb
PubMed​查找	[5]	[6]
维基数据
查看/编辑人类 查看/编辑小鼠

8 sources

相互作用

层粘蛋白亚基α1会与FBLN2（英语：FBLN2）发生蛋白质相互作用^[9][10]。

2 sources

参考资料

1. 與LAMA1相關的疾病；在維基數據上查看/編輯參考.
2. 對Laminin subunit alpha 1起作用的藥物；在維基數據上查看/編輯參考.
3. GRCh38: Ensembl release 89: ENSG00000101680 - Ensembl, May 2017
4. GRCm38: Ensembl release 89: ENSMUSG00000032796 - Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. Nagayoshi, T.; Mattei, M. G.; Passage, E.; Knowlton, R.; Chu, M. L.; Uitto, J. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. Genomics. 1989-11, 5 (4): 932–935 [2021-11-10]. ISSN 0888-7543. PMID 2591971. doi:10.1016/0888-7543(89)90136-5. （原始内容存档于2021-11-10）.
8. LAMA1 laminin subunit alpha 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.
9. Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）.
10. Talts, J. F.; Sasaki, T.; Miosge, N.; Göhring, W.; Mann, K.; Mayne, R.; Timpl, R. Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues. The Journal of Biological Chemistry. 2000-11-10, 275 (45): 35192–35199 [2021-11-10]. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200. （原始内容存档于2022-01-21）.

拓展阅读

• Haaparanta, T.; Uitto, J.; Ruoslahti, E.; Engvall, E. Molecular cloning of the cDNA encoding human laminin A chain. Matrix (Stuttgart, Germany). 1991-06, 11 (3): 151–160 [2021-11-10]. ISSN 0934-8832. PMID 1714537. doi:10.1016/s0934-8832(11)80153-8. （原始内容存档于2021-11-10）.
• Nissinen, M; Vuolteenaho, R; Boot-Handford, R; Kallunki, P; Tryggvason, K. Primary structure of the human laminin A chain. Limited expression in human tissues. Biochemical Journal. 1991-06-01, 276 (2): 369–379 [2021-11-10]. ISSN 0264-6021. PMC 1151101 . PMID 2049067. doi:10.1042/bj2760369. （原始内容存档于2021-08-12） （英语）.
• Taraboletti, G.; Rao, C. N.; Krutzsch, H. C.; Liotta, L. A.; Roberts, D. D. Sulfatide-binding domain of the laminin A chain. The Journal of Biological Chemistry. 1990-07-25, 265 (21): 12253–12258 [2021-11-10]. ISSN 0021-9258. PMID 2373692. （原始内容存档于2021-11-10）.
• Olsen, D.; Nagayoshi, T.; Fazio, M.; Peltonen, J.; Jaakkola, S.; Sanborn, D.; Sasaki, T.; Kuivaniemi, H.; Chu, M. L. Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. Laboratory Investigation; a Journal of Technical Methods and Pathology. 1989-06, 60 (6): 772–782 [2021-11-10]. ISSN 0023-6837. PMID 2733383. （原始内容存档于2021-11-10）.
• Leivo, I; Engvall, E. C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast.. The Journal of Cell Biology. 1986-09-01, 103 (3): 1091–1100 [2021-11-10]. ISSN 0021-9525. PMC 2114300 . PMID 3488995. doi:10.1083/jcb.103.3.1091. （原始内容存档于2022-01-21） （英语）.
• Wewer, U. M.; Gerecke, D. R.; Durkin, M. E.; Kurtz, K. S.; Mattei, M. G.; Champliaud, M. F.; Burgeson, R. E.; Albrechtsen, R. Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas. Genomics. 1994-11-15, 24 (2): 243–252 [2021-11-10]. ISSN 0888-7543. PMID 7698745. doi:10.1006/geno.1994.1612. （原始内容存档于2021-11-10）.
• Yamada, H.; Shimizu, T.; Tanaka, T.; Campbell, K. P.; Matsumura, K. Dystroglycan is a binding protein of laminin and merosin in peripheral nerve. FEBS letters. 1994-09-19, 352 (1): 49–53 [2021-11-10]. ISSN 0014-5793. PMID 7925941. doi:10.1016/0014-5793(94)00917-1. （原始内容存档于2022-03-13）.
• Moser, T. L.; Enghild, J. J.; Pizzo, S. V.; Stack, M. S. The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. The Journal of Biological Chemistry. 1993-09-05, 268 (25): 18917–18923 [2021-11-10]. ISSN 0021-9258. PMID 8360181. （原始内容存档于2021-11-10）.、
• Yurchenco, P. D.; Sung, U.; Ward, M. D.; Yamada, Y.; O'Rear, J. J. Recombinant laminin G domain mediates myoblast adhesion and heparin binding. The Journal of Biological Chemistry. 1993-04-15, 268 (11): 8356–8365 [2021-11-10]. ISSN 0021-9258. PMID 8463343. （原始内容存档于2021-11-10）.
• Ancsin, J. B.; Kisilevsky, R. Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A. The Journal of Biological Chemistry. 1997-01-03, 272 (1): 406–413 [2021-11-10]. ISSN 0021-9258. PMID 8995276. doi:10.1074/jbc.272.1.406. （原始内容存档于2021-11-10）.
• Zahedi, K. Characterization of the binding of serum amyloid P to laminin. The Journal of Biological Chemistry. 1997-01-24, 272 (4): 2143–2148 [2021-11-10]. ISSN 0021-9258. PMID 8999915. （原始内容存档于2021-11-10）.
• Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）.
• Cáceres, J.; Brandan, E. Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. Journal of Cellular Biochemistry. 1997-05, 65 (2): 145–158 [2021-11-10]. ISSN 0730-2312. PMID 9136074. doi:10.1002/(sici)1097-4644(199705)65:2<145::aid-jcb2>3.0.co;2-u. （原始内容存档于2021-11-10）.
• Chen, M.; Marinkovich, M. P.; Veis, A.; Cai, X.; Rao, C. N.; O'Toole, E. A.; Woodley, D. T. Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin. The Journal of Biological Chemistry. 1997-06-06, 272 (23): 14516–14522 [2021-11-10]. ISSN 0021-9258. PMID 9169408. doi:10.1074/jbc.272.23.14516. （原始内容存档于2022-04-06）.
• Schuger, L.; Skubitz, A. P.; Zhang, J.; Sorokin, L.; He, L. Laminin alpha1 chain synthesis in the mouse developing lung: requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development. The Journal of Cell Biology. 1997-10-20, 139 (2): 553–562 [2021-11-10]. ISSN 0021-9525. PMC 2139794 . PMID 9334356. doi:10.1083/jcb.139.2.553. （原始内容存档于2021-11-10）.
• Mrowiec, T.; Melchar, C.; Górski, A. HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. Archivum Immunologiae Et Therapiae Experimentalis. 1997, 45 (2-3): 255–259 [2021-11-10]. ISSN 0004-069X. PMID 9597096. （原始内容存档于2021-11-10）.
• O'Grady, P.; Thai, T. C.; Saito, H. The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. The Journal of Cell Biology. 1998-06-29, 141 (7): 1675–1684 [2021-11-10]. ISSN 0021-9525. PMC 2133008 . PMID 9647658. doi:10.1083/jcb.141.7.1675. （原始内容存档于2021-11-10）.
• Ettner, N.; Göhring, W.; Sasaki, T.; Mann, K.; Timpl, R. The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan. FEBS letters. 1998-07-03, 430 (3): 217–221 [2021-11-10]. ISSN 0014-5793. PMID 9688542. doi:10.1016/s0014-5793(98)00601-2. （原始内容存档于2021-11-10）.
• Ludwig, H. C.; Rausch, S.; Schallock, K.; Markakis, E. Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry. Anticancer Research. 1999-05, 19 (3A): 1747–1752 [2021-11-10]. ISSN 0250-7005. PMID 10470109. （原始内容存档于2021-11-10）.