MC4受體,即MC4R,是在人體中由MC4R基因編碼的黑素皮質素受體[7][8][9]。它編碼MC4蛋白。在小鼠中,已發現MC4受體參與進食行為,代謝,性行為和男性勃起功能的調節[10][11][12]。
Quick Facts 黑素皮質素受體4, 已知的結構 ...
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據2008年的報導,MC4R突變與人類遺傳性肥胖有關[13]。在體重指數大於30的人群中,該病的患病率為1.0–2.5%,是最容易導致肥胖的最常見遺傳缺陷。[來源請求]
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Loos, Ruth J. F.; Lindgren, Cecilia M.; Li, Shengxu; Wheeler, Eleanor; Zhao, Jing Hua; Prokopenko, Inga; Inouye, Michael; Freathy, Rachel M.; Attwood, Antony P.; Beckmann, Jacques S.; Berndt, Sonja I. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics. June 2008, 40 (6): 768–775. ISSN 1546-1718. PMC 2669167 . PMID 18454148. doi:10.1038/ng.140.