孕酮受體(英語:progesterone receptor,縮寫PR,也被稱為NR3C3 ,nuclear receptor subfamily 3, group C, member 3,即核受體第三亞族C組成員3)是一種細胞內蛋白質,由甾體激素孕酮激活。
Quick Facts Progesterone receptor 孕酮受體, 有效結構 ...
Progesterone receptor 孕酮受體 |
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PDB rendering based on 1a28. |
有效結構 |
PDB |
直系同源檢索:PDBe, RCSB
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PDB查詢代碼列表 |
1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU
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代號 |
PGR; NR3C3; PR |
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擴展標識 |
遺傳學:607311 鼠基因:97567 同源基因:713 IUPHAR: ChEMBL: 208 GeneCards: PGR Gene |
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更多表達數據 |
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物種 |
人類 |
小鼠 |
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Entrez |
5241 |
18667 |
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Ensembl |
ENSG00000082175 |
ENSMUSG00000031870 |
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UniProt |
P06401 |
n/a |
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mRNA序列 |
NM_000926 |
NM_008829 |
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蛋白序列 |
NP_000917 |
NP_032855 |
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基因位置 |
Chr 11: 100.9 – 101 Mb |
Chr 9: 8.9 – 8.97 Mb |
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PubMed查詢 |
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在人體中,孕酮受體由基因PGR 編碼,位於11號染色體長臂22區[1][2][3],能通過選擇性剪接形成兩種蛋白異形體A和B,有着各自不同的分子量[4][5][6]。
孕酮是引起孕酮受體反應的配體,在孕酮受體的C端未結合該激素時,與其相關的DNA片段的轉錄處於抑制狀態。在與激素結合後,孕酮受體會變構並開始起作用。而孕酮受體的受體拮抗劑會阻止這種結構改變。
在孕酮與其受體結合後,孕酮受體變構並發生二聚化,緊接着以複合體形式進入細胞核與相關的DNA結合,從而使其開始轉錄,合成mRNA,並表達為相關蛋白質。
Quick Facts Progesterone receptor, N-terminal, 鑑定 ...
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和其它甾體激素受體類似,孕酮受體的N端有一個調控結構域,一個DNA結合結構域,以及一個鉸鏈區,在C端有一個配體結合結構域。異形體B比異形體A多一個TAF-3區域。
孕酮受體能與下列蛋白質發生交互作用:
- KLF9[7]
- Nuclear receptor co-repressor 2[8]
- UBE3A[9]
- Selective progesterone receptor modulator
Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E. Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem. Biophys. Res. Commun. March 1987, 143 (2): 740–8. PMID 3551956. doi:10.1016/0006-291X(87)91416-1.
Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW. The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2. Proc. Natl. Acad. Sci. U.S.A. May 1987, 84 (9): 2877–81. PMC 304763 . PMID 3472240. doi:10.1073/pnas.84.9.2877.
Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C. Progesterone receptors: various forms and functions in reproductive tissues. Front. Biosci. 2005, 10: 2118–30. PMID 15970482. doi:10.2741/1685.
Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC. Selective interactions of Kruppel-like factor 9/basic transcription element-binding protein with progesterone receptor isoforms A and B determine transcriptional activity of progesterone-responsive genes in endometrial epithelial cells. J. Biol. Chem. June 2003, 278 (24): 21474–82. PMID 12672823. doi:10.1074/jbc.M212098200.
- Butnor KJ, Burchette JL, Robboy SJ. Progesterone receptor activity in leiomyomatosis peritonealis disseminata. Int. J. Gynecol. Pathol. 2002, 18 (3): 259–64. PMID 12090595. doi:10.1097/00004347-199907000-00012.
- Leonhardt SA, Boonyaratanakornkit V, Edwards DP. Progesterone receptor transcription and non-transcription signaling mechanisms. Steroids. 2004, 68 (10–13): 761–70. PMID 14667966. doi:10.1016/S0039-128X(03)00129-6.
- Conneely OM, Mulac-Jericevic B, Lydon JP. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids. 2004, 68 (10–13): 771–8. PMID 14667967. doi:10.1016/S0039-128X(03)00126-0.
- Bagchi MK, Tsai SY, Tsai MJ, O'Malley BW. Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (7): 2664–8. PMC 48722 . PMID 1557371. doi:10.1073/pnas.89.7.2664.
- Kastner P, Krust A, Turcotte B; et al. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J. 1990, 9 (5): 1603–14. PMC 551856 . PMID 2328727.
- Guiochon-Mantel A, Loosfelt H, Lescop P; et al. Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers. Cell. 1989, 57 (7): 1147–54. PMID 2736623. doi:10.1016/0092-8674(89)90052-4.
- Fernandez MD, Carter GD, Palmer TN. The interaction of canrenone with oestrogen and progesterone receptors in human uterine cytosol. British Journal of Clinical Pharmacology. 1983, 15 (1): 95–101. PMC 1427833 . PMID 6849751. doi:10.1111/j.1365-2125.1983.tb01470.x.
- Oñate SA, Tsai SY, Tsai MJ, O'Malley BW. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science. 1995, 270 (5240): 1354–7. PMID 7481822. doi:10.1126/science.270.5240.1354.
- Zhang Y, Beck CA, Poletti A; et al. Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II. J. Biol. Chem. 1995, 269 (49): 31034–40. PMID 7983041.
- Mansour I, Reznikoff-Etievant MF, Netter A. No evidence for the expression of the progesterone receptor on peripheral blood lymphocytes during pregnancy. Hum. Reprod. 1995, 9 (8): 1546–9. PMID 7989520.
- Kalkhoven E, Wissink S, van der Saag PT, van der Burg B. Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor. J. Biol. Chem. 1996, 271 (11): 6217–24. PMID 8626413. doi:10.1074/jbc.271.11.6217.
- Wang JD, Zhu JB, Fu Y; et al. Progesterone receptor immunoreactivity at the maternofetal interface of first trimester pregnancy: a study of the trophoblast population. Hum. Reprod. 1996, 11 (2): 413–9. PMID 8671234. doi:10.1093/humrep/11.2.413.
- Thénot S, Henriquet C, Rochefort H, Cavaillès V. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J. Biol. Chem. 1997, 272 (18): 12062–8. PMID 9115274. doi:10.1074/jbc.272.18.12062.
- Jenster G, Spencer TE, Burcin MM; et al. Steroid receptor induction of gene transcription: a two-step model. Proc. Natl. Acad. Sci. U.S.A. 1997, 94 (15): 7879–84. PMC 21523 . PMID 9223281. doi:10.1073/pnas.94.15.7879.
- Shanker YG, Sharma SC, Rao AJ. Expression of progesterone receptor mRNA in the first trimester human placenta. Biochem. Mol. Biol. Int. 1997, 42 (6): 1235–40. PMID 9305541.
- Richer JK, Lange CA, Wierman AM; et al. Progesterone receptor variants found in breast cells repress transcription by wild-type receptors. Breast Cancer Res. Treat. 1998, 48 (3): 231–41. PMID 9598870. doi:10.1023/A:1005941117247.
- Williams SP, Sigler PB. Atomic structure of progesterone complexed with its receptor. Nature. 1998, 393 (6683): 392–6. PMID 9620806. doi:10.1038/30775.
- Boonyaratanakornkit V, Melvin V, Prendergast P; et al. High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells. Mol. Cell. Biol. 1998, 18 (8): 4471–87. PMC 109033 . PMID 9671457.
- Nawaz Z, Lonard DM, Smith CL; et al. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol. Cell. Biol. 1999, 19 (2): 1182–9. PMC 116047 . PMID 9891052.
此條目包含有源於Pfam以及InterPro的屬於公有領域的文本 IPR000342