CD18

CD18
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	1L3Y、1YUK、2JF1、2P26、2P28、3K6S、3K71、3K72、2V7D、4NEH、4NEN、5E6X、5E6V、5E6S、5E6R、5E6W、5ES4、5E6U
識別號
別名	ITGB2；, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
外部ID	OMIM：600065 MGI：96611 HomoloGene：20092 GeneCards：ITGB2
相關疾病
	leukocyte adhesion deficiency-1
基因位置（人類）
染色體	21號染色體
終止	44,931,989 bp
基因位置（小鼠）
染色體	小鼠10號染色體
終止	77,401,542 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• 大分子複合物結合; • 金屬離子結合; • 血漿蛋白結合; • protein heterodimerization activity; • ICAM-3 receptor activity; • protein kinase binding; • cell adhesion molecule binding; • heat shock protein binding; • amyloid-beta binding; • complement component C3b binding; • integrin binding; • signaling receptor activity; • cargo receptor activity;
細胞組分	• integral component of membrane; • 細胞外囊泡; • integrin alphaL-beta2 complex; • 膜; • 細胞膜; • receptor complex; • cell surface; • integrin complex; • 外排體; • specific granule membrane; • tertiary granule membrane; • ficolin-1-rich granule membrane; • 粘着斑; • external side of plasma membrane; • integrin alphaM-beta2 complex; • plasma membrane raft; • 脂筏模型; • cytoplasmic region; • 大分子複合體;
生物學過程	• leukocyte cell-cell adhesion; • endodermal cell differentiation; • toll-like receptor 4 signaling pathway; • positive regulation of nitric oxide biosynthetic process; • heterotypic cell-cell adhesion; • cell-cell signaling; • 老化; • receptor internalization; • leukocyte migration involved in inflammatory response; • natural killer cell activation; • cellular response to low-density lipoprotein particle stimulus; • extracellular matrix organization; • receptor clustering; • positive regulation of angiogenesis; • neutrophil chemotaxis; • 細胞粘附; • positive regulation of NF-kappaB transcription factor activity; • regulation of cell shape; • regulation of immune response; • cellular extravasation; • integrin-mediated signaling pathway; • cell-matrix adhesion; • inflammatory response; • endothelial cell migration; • leukocyte migration; • regulation of peptidyl-tyrosine phosphorylation; • 細胞凋亡; • 吞噬作用; • neutrophil degranulation; • microglial cell activation; • 受體介導的內吞作用; • phagocytosis, engulfment; • 細胞遷移; • cytokine-mediated signaling pathway; • positive regulation of superoxide anion generation; • cell adhesion mediated by integrin; • positive regulation of neutrophil degranulation; • negative regulation of dopamine metabolic process; • positive regulation of protein targeting to membrane; • amyloid-beta clearance; • cell-cell adhesion; • cell-cell adhesion via plasma-membrane adhesion molecules; • positive regulation of neuron death; • positive regulation of microglial cell activation; • neutrophil migration; • positive regulation of prostaglandin-E synthase activity; • positive regulation of leukocyte adhesion to vascular endothelial cell;
	Sources:Amigo / QuickGO
直系同源
	3689
	16414
	ENSG00000160255
	ENSMUSG00000000290
	P05107
	P11835
	NM_000211; NM_001127491; NM_001303238
	NM_008404
	NP_000202; NP_001120963; NP_001290167
	NP_032430
	維基數據
檢視/編輯人類	檢視/編輯小鼠