在分子生物學中,5.8S核糖體RNA(5.8S rRNA)是指一類非編碼RNA。它是真核生物核糖體的大亞基的組成成分,在蛋白質轉譯中起重要作用。RNA聚合酶I先轉錄出沉降系數爲45S的前體。該前體同樣包含18S rRNA和28S rRNA。5.8S rRNA在核糖體轉運中起作用[1]。它能夠和p53腫瘤抑制蛋白形成共價連接[2]。
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