5-HT2B受體

5-羥色胺受體2B或血清素受體2B (英語:5-Hydroxytryptamine receptor 2B (5-HT_2B)或serotonin receptor 2B) 是在人類中由HTR2B基因編碼的蛋白質^[6][7]。 5-HT_2B是5-HT2受體家族中的成員。

5-HT2B受體
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 4NC3、​4IB4
識別號
別名	HTR2B；, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B
外部ID	OMIM：601122 MGI：109323 HomoloGene：55492 GeneCards：HTR2B
為以下藥物的標靶
LSD、​5-carboxamidotryptamine、​血清素、​8-OH-DPAT、​AL-37350A、​α-methyl-5-HT、​布苯丙胺、​BW-723C86、​過乳降、​CGS-12066A、​2,5-二甲氧基-4-碘代苯丙胺、​洛卡色林、​MK-212、​norfenfluramine、​Org 12962、​ORG-37684、​培高利特、​吲哚洛爾、​quinpirole、​喹匹配拉淨、​ru-24969、​N-(3-三氟甲基苯基)匹配拉淨、​色胺、​VER-3323、​brl-15572、​邁克寧（又譯麥角胺）、​gr-127935、​間氯苯基匹配拉淨、​甲基麥角新鹼、​美西麥角、​sb-216641、​1-naphthylpiperazine、​阿戈美拉汀、​阿樸嗎啡、​溴隱亭、​氯氮平、​氟西汀、​glemanserin、​氟哌啶醇、​酮色林、​L-741,626、​麥角乙脲、​褪黑素、​mesulergine、​甲麥角林、​metitepine、​米塞林、​seproxetine、​哌波色羅、​吡貝地爾、​蘿芙木、​ritanserin、​roxindole、​RS-102221、​RS-127445、​sarpogrelate、​SB 204741、​sb-206553、​SB 242084、​SB 243213、​SB-277,011-A、​SDZ SER-082、​spiperone、​spiramide、​spiroxatrine、​特麥角脲、​曲唑酮、​volinanserin、​呫諾美林、​育亨賓、​齊美定[1]
基因位置（人類） 染色體 2號染色體[2] 基因座 2q37.1 起始 231,108,230 bp[2] 終止 231,125,042 bp[2]
基因位置（小鼠） 染色體 小鼠1號染色體[3] 基因座 1|1 C5 起始 86,026,748 bp[3] 終止 86,039,692 bp[3]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • G protein-coupled receptor activity • GTPase activator activity • signal transducer activity • G protein-coupled serotonin receptor activity • G-protein alpha-subunit binding • serotonin binding • neurotransmitter receptor activity 細胞組分 • 細胞質 • integral component of membrane • 膜 • 細胞膜 • 突觸 • 細胞連接 • neuron projection • integral component of plasma membrane • 核質 • 樹突 生物學過程 • intestine smooth muscle contraction • 平滑肌收縮 • G protein-coupled receptor internalization • release of sequestered calcium ion into cytosol • regulation of behavior • positive regulation of endothelial cell proliferation • positive regulation of MAP kinase activity • 磷酸化 • positive regulation of cytokine production • 血管收縮 • ERK1 and ERK2 cascade • positive regulation of phosphatidylinositol biosynthetic process • cardiac muscle hypertrophy • heart morphogenesis • cellular calcium ion homeostasis • neural crest cell differentiation • negative regulation of apoptotic process • negative regulation of cell death • activation of phospholipase C activity • protein kinase C signaling • cGMP biosynthetic process • cellular response to temperature stimulus • positive regulation of GTPase activity • 心臟發育 • positive regulation of nitric-oxide synthase activity • protein kinase C-activating G protein-coupled receptor signaling pathway • embryonic morphogenesis • serotonin receptor signaling pathway • neural crest cell migration • positive regulation of cell population proliferation • positive regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • phosphatidylinositol 3-kinase signaling • negative regulation of autophagy • positive regulation of cell division • calcium-mediated signaling • 信號轉導 • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • G protein-coupled receptor signaling pathway • 動物行為 • cGMP-mediated signaling • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • 化學性突觸傳遞 Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3357	15559
Ensembl	ENSG00000135914	ENSMUSG00000026228
UniProt	P41595	Q02152
mRNA​序列	NM_000867 ​NM_001320758	NM_008311
蛋白序列	NP_000858 ​NP_001307687	NP_032337
基因位置​（UCSC）	Chr 2: 231.11 – 231.13 Mb	Chr 1: 86.03 – 86.04 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

參見

• 5-羥色胺受體

參考資料

1. 對5-HT2B受體起作用的藥物；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000135914 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000026228 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Entrez Gene: HTR_2B 5-hydroxytryptamine (serotonin) receptor 2B. （原始內容存檔於2019-09-18）.
7. Schmuck K, Ullmer C, Engels P, Lübbert H. Cloning and functional characterization of the human 5-HT2B serotonin receptor. FEBS Letters. Mar 1994, 342 (1): 85–90 [2017-01-24]. PMID 8143856. doi:10.1016/0014-5793(94)80590-3. （原始內容存檔於2019-02-15）.

深入閱讀

• Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN. Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacology & Therapeutics. 2002, 92 (2-3): 179–212. PMID 11916537. doi:10.1016/S0163-7258(01)00169-3.
• Bonhaus DW, Bach C, DeSouza A, Salazar FH, Matsuoka BD, Zuppan P, Chan HW, Eglen RM. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. British Journal of Pharmacology. Jun 1995, 115 (4): 622–8. PMC 1908489 . PMID 7582481. doi:10.1111/j.1476-5381.1995.tb14977.x.
• Choi DS, Birraux G, Launay JM, Maroteaux L. The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Letters. Oct 1994, 352 (3): 393–9. PMID 7926008. doi:10.1016/0014-5793(94)00968-6.
• Kursar JD, Nelson DL, Wainscott DB, Baez M. Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor. Molecular Pharmacology. Aug 1994, 46 (2): 227–34. PMID 8078486.
• Schmuck K, Ullmer C, Engels P, Lübbert H. Cloning and functional characterization of the human 5-HT2B serotonin receptor. FEBS Letters. Mar 1994, 342 (1): 85–90. PMID 8143856. doi:10.1016/0014-5793(94)80590-3.
• Launay JM, Birraux G, Bondoux D, Callebert J, Choi DS, Loric S, Maroteaux L. Ras involvement in signal transduction by the serotonin 5-HT2B receptor. The Journal of Biological Chemistry. Feb 1996, 271 (6): 3141–7. PMID 8621713. doi:10.1074/jbc.271.6.3141.
• Le Coniat M, Choi DS, Maroteaux L, Launay JM, Berger R. The 5-HT2B receptor gene maps to 2q36.3-2q37.1. Genomics. Feb 1996, 32 (1): 172–3. PMID 8786115. doi:10.1006/geno.1996.0101.
• Kim SJ, Veenstra-VanderWeele J, Hanna GL, Gonen D, Leventhal BL, Cook EH. Mutation screening of human 5-HT(2B)receptor gene in early-onset obsessive-compulsive disorder. Molecular and Cellular Probes. Feb 2000, 14 (1): 47–52. PMID 10722792. doi:10.1006/mcpr.1999.0281.
• Manivet P, Mouillet-Richard S, Callebert J, Nebigil CG, Maroteaux L, Hosoda S, Kellermann O, Launay JM. PDZ-dependent activation of nitric-oxide synthases by the serotonin 2B receptor. The Journal of Biological Chemistry. Mar 2000, 275 (13): 9324–31. PMID 10734074. doi:10.1074/jbc.275.13.9324.
• Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C. Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. The Journal of Biological Chemistry. Apr 2001, 276 (16): 12974–82. PMID 11150294. doi:10.1074/jbc.M008089200.
• Manivet P, Schneider B, Smith JC, Choi DS, Maroteaux L, Kellermann O, Launay JM. The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis. The Journal of Biological Chemistry. May 2002, 277 (19): 17170–8. PMID 11859080. doi:10.1074/jbc.M200195200.
• Borman RA, Tilford NS, Harmer DW, Day N, Ellis ES, Sheldrick RL, Carey J, Coleman RA, Baxter GS. 5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro. British Journal of Pharmacology. Mar 2002, 135 (5): 1144–51. PMC 1573235 . PMID 11877320. doi:10.1038/sj.bjp.0704571.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene. May 2003, 22 (21): 3307–18. PMID 12761501. doi:10.1038/sj.onc.1206406.
• Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J. Functional activity of serotoninergic and melatoninergic systems expressed in the skin. Journal of Cellular Physiology. Jul 2003, 196 (1): 144–53. PMID 12767050. doi:10.1002/jcp.10287.
• Lin Z, Walther D, Yu XY, Drgon T, Uhl GR. The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse. Pharmacogenetics. Dec 2004, 14 (12): 805–11. PMID 15608559. doi:10.1097/00008571-200412000-00003.

外部連結

• 5-HT_2B. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. （原始內容存檔於2017-02-02）.
• Human HTR2B genome location and HTR2B gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.

5-HT2B受體引用了美國國家醫學圖書館提供的數據，這些數據屬於公共領域。

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