胰島素樣生長因子1

胰島素樣生長因子1（英語：Insulin-like growth factor 1，IGF-1）也被稱為生長調節素C（somatomedin C），是一個由人類基因 IGF1 編碼的蛋白質^[6][7]。在1970年代，IGF-1也曾經被稱為「酸硫化（英語：sulfation）因子」^[8]，並認為其作用為「不受抑制的胰島樣活力」（nonsuppressible insulin-like activity，NSILA）。

胰島素樣生長因子1
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 1B9G、​1GZR、​1GZY、​1GZZ、​1H02、​1H59、​1IMX、​1PMX、​1TGR、​1WQJ、​2DSR、​2GF1、​3GF1、​3LRI、​1BQT、​4XSS
識別號
別名	IGF1；, IGF-I, IGF1A, IGFI, MGF, insulin like growth factor 1, IGF
外部ID	OMIM：147440 MGI：96432 HomoloGene：515 GeneCards：IGF1
相關疾病
growth delay due to insulin-like growth factor type 1 deficiency[1]
基因位置（人類） 染色體 12號染色體[2] 基因座 12q23.2 起始 102,395,874 bp[2] 終止 102,481,744 bp[2]
基因位置（小鼠） 染色體 小鼠10號染色體[3] 基因座 10 C1|10 43.7 cM 起始 87,694,127 bp[3] 終止 87,772,904 bp[3]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • hormone activity • insulin receptor binding • 生長因子活性 • integrin binding • 血漿蛋白結合 • insulin-like growth factor receptor binding 細胞組分 • 細胞外區域 • exocytic vesicle • insulin-like growth factor binding protein complex • platelet alpha granule lumen • insulin-like growth factor ternary complex • alphav-beta3 integrin-IGF-1-IGF1R complex • 細胞膜 • 細胞外空間 生物學過程 • positive regulation of transcription regulatory region DNA binding • 骨骼系統的發生 • positive regulation of glucose import • muscle organ development • positive regulation of Ras protein signal transduction • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • 脫氧核糖核酸複製 • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • 細胞增殖 • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • 基因調節 • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • 肌肉肥大 • Akt/PKB信號通路 • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • 信號轉導 • positive regulation of transcription by RNA polymerase II • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of cell population proliferation • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • negative regulation of apoptotic process • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • positive regulation of gene expression • negative regulation of gene expression • cellular response to amyloid-beta • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell apoptotic process • 白血球介素-1β產生的負調控 • 腫瘤壞死因子產生的負調控 • negative regulation of neuroinflammatory response • negative regulation of amyloid-beta formation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3479	16000
Ensembl	ENSG00000017427	ENSMUSG00000020053
UniProt	P05019	P05017
mRNA​序列	NM_000618 ​NM_001111283 ​NM_001111284 ​NM_001111285	NM_001111274 ​NM_001111275 ​NM_001111276 ​NM_010512 ​NM_184052 ​NM_001314010
蛋白序列	NP_000609 ​NP_001104753 ​NP_001104754 ​NP_001104755	NP_001104744 ​NP_001104745 ​NP_001104746 ​NP_001300939 ​NP_034642
基因位置​（UCSC）	Chr 12: 102.4 – 102.48 Mb	Chr 10: 87.69 – 87.77 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

IGF-1是一個在三級結構上與胰島素類似的激素，在兒童成長發育中有重要作用，並持續在成人的合成代謝中起作用。一種人工合成的IGF-1類似物，美卡舍明（英語：mecasermin），用於治療發育停滯^[9]。

IGF-1蛋白由一個肽鏈構成，包括70個氨基酸殘基和三個分子內二硫鍵，分子量為7,649道爾頓^[10]。

已經發現,垂體前部的生長激素（GH）分泌受到GH釋放激素( GHRH )和生長抑素的調節，GHRH和生長抑素之間的相互作用引起搏動性GH分泌，在青春期最高。GH誘導肝臟中胰島素樣生長因子1的產生，並調節許多其他組織中IGF-1的旁分泌。IGF-1是GH的合成代謝和促有絲分裂活性的介體。

參考文獻

1. 與胰岛素样生长因子1相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000017427 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000020053 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum. Genet. 1985, 69 (2): 157–60. PMID 2982726. doi:10.1007/BF00293288.
7. Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL. Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature. 1983, 306 (5943): 609–11. PMID 6358902. doi:10.1038/306609a0.
8. Salmon WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med. 1957, 49 (6): 825–36. PMID 13429201.
9. Keating GM. Mecasermin. BioDrugs. 2008, 22 (3): 177–88. PMID 18481900. doi:10.2165/00063030-200822030-00004.
10. Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem. 1978, 253 (8): 2769–2776. PMID 632300.

延伸閱讀

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外部連結

• 醫學主題詞表（MeSH）：Insulin-Like+Growth+Factor+I
• IGF-1 （頁面存檔備份，存於互聯網檔案館） at Lab Tests Online
• IGF-1 （頁面存檔備份，存於互聯網檔案館） recombinant GFP labeled at Protean Ltd. （頁面存檔備份，存於互聯網檔案館）