丙咪嗪

丙咪嗪是一種口服三環類抗抑鬱藥，主要用於治療抑鬱。它還可以治療焦慮和恐慌症。^[5][6][7]

丙咪嗪

臨床資料
商品名（英語：Drug nomenclature）	Tofranil, Tofranil-PM, others
其他名稱	Melipramine; G-22355
AHFS/Drugs.com	Monograph
MedlinePlus	a682389
核准狀況	美 DailyMed: Imipramine
懷孕分級	澳: C [1]
給藥途徑	By mouth, intramuscular injection
ATC碼	N06AA02 (WHO)
法律規範狀態
法律規範	澳：限醫生處方（S4） 加：處方藥（℞-only） 英：處方藥（℞-only） (POM) 美：處方藥（℞-only）
藥物動力學數據
生物利用度	94–96%[2]
血漿蛋白結合率	86%[3]
藥物代謝	Liver (CYP1A2, CYP2C19, CYP2D6)[3]
代謝產物	Desipramine[3]
生物半衰期	20 hours[3]
排泄途徑	Kidney (80%), fecal (20%)[3]
識別資訊
IUPAC命名法 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
CAS號	50-49-7  Y
PubChem CID	3696
IUPHAR/BPS	357
DrugBank	DB00458 Y
ChemSpider	3568 Y
UNII	OGG85SX4E4
KEGG	D08070 Y as HCl: D00815 Y
ChEBI	CHEBI:47499 Y
ChEMBL	ChEMBL11 Y
PDB配體ID	IXX (PDBe, RCSB PDB)
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID1043881
ECHA InfoCard	100.000.039
化學資訊
化學式	C19H24N2
摩爾質量	280.42 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像
SMILES CN(C)CCCN1c2ccccc2CCc2ccccc21
InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 Y Key:BCGWQEUPMDMJNV-UHFFFAOYSA-N Y

丙咪嗪的常見副作用有口乾、昏睡、頭暈、低血壓、心跳過速、尿瀦留。丙咪嗪過量可能會導致死亡。

丙咪嗪於1951年被發現，並於1957年投入臨床使用。

參考文獻

1. Imipramine Use During Pregnancy. Drugs.com. 28 August 2019 [7 February 2020]. （原始內容存檔於2020-02-07）.
2. Heck HA, Buttrill SE, Flynn NW, Dyer RL, Anbar M, Cairns T, et al. Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: increasing the power of bioavailability tests. Journal of Pharmacokinetics and Biopharmaceutics. June 1979, 7 (3): 233–248. PMID 480146. S2CID 23232584. doi:10.1007/BF01060015.
3. Product Information Tolerade (imipramine hydrochloride). TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013 [16 October 2013]. （原始內容存檔於10 December 2019）.
4. Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-03-31 (2023-04-04) [2023-08-16]. （原始內容存檔於2023-08-03） （巴西葡萄牙語）. 請檢查|publication-date=中的日期值 (幫助)
5. Robert R, Blakeney PE, Villarreal C, Rosenberg L, Meyer WJ. Imipramine treatment in pediatric burn patients with symptoms of acute stress disorder: a pilot study. Journal of the American Academy of Child and Adolescent Psychiatry. July 1999, 38 (7): 873–882. PMID 10405506. doi:10.1097/00004583-199907000-00018.
6. Tcheung WJ, Robert R, Rosenberg L, Rosenberg M, Villarreal C, Thomas C, et al. Early treatment of acute stress disorder in children with major burn injury. Pediatric Critical Care Medicine. November 2005, 6 (6): 676–681. PMID 16276335. S2CID 43261789. doi:10.1097/01.pcc.0000165562.04157.da.
7. Robert R, Tcheung WJ, Rosenberg L, Rosenberg M, Mitchell C, Villarreal C, et al. Treating thermally injured children suffering symptoms of acute stress with imipramine and fluoxetine: a randomized, double-blind study. Burns. November 2008, 34 (7): 919–928. PMID 18675519. doi:10.1016/j.burns.2008.04.009.