CD66b

CD66b（cluster of differentiation 66，分化簇66b，也稱為「癌胚抗原相關細胞黏附分子8」，Carcinoembryonic antigen-related cell adhesion molecule 8，縮寫CEACAM8）是一種細胞表面蛋白質，屬於癌胚抗原（CEA）蛋白質家族，通過糖磷脂酰肌醇（GPI）錨定在細胞膜上，在顆粒白血球上高表達，可作為顆粒白血球的標誌物，參與細胞黏附、細胞遷移和病原體識別^[3] 。

CEACAM8
已知的結構 PDB 人類UniProt搜尋: PDBe RCSB PDBID列表 2DKS、​4Y88、​4YIQ、​4WTZ
識別號
別名	CEACAM8；, CD66b, CD67, CGM6, NCA-95, carcinoembryonic antigen related cell adhesion molecule 8, CEA cell adhesion molecule 8
外部ID	OMIM：615747 HomoloGene：68205 GeneCards：CEACAM8
基因位置（人類） 染色體 19號染色體[1] 基因座 19q13.2 起始 42,580,243 bp[1] 終止 42,595,055 bp[1]
基因本體 分子功能 • 血漿蛋白結合 • protein heterodimerization activity 細胞組分 • anchored component of membrane • 細胞膜 • integral component of plasma membrane • 外排體 • 膜 • 細胞外空間 • azurophil granule membrane • specific granule membrane • tertiary granule membrane • cell surface 生物學過程 • 免疫反應 • leukocyte migration • neutrophil degranulation • 細胞粘附 • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	1088	無數據
Ensembl	ENSG00000124469	無數據
UniProt	P31997	無數據
mRNA​序列	NM_001816	無數據
蛋白序列	NP_001807	無數據
基因位置​（UCSC）	Chr 19: 42.58 – 42.6 Mb	無數據
PubMed​查找	[2]	無數據
維基數據
檢視/編輯人類

參考文獻

1. GRCh38: Ensembl release 89: ENSG00000124469 - Ensembl, May 2017
2. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Entrez Gene: CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8.

延伸閱讀

• Khan WN, Frängsmyr L, Teglund S, et al. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family.. Genomics. 1992, 14 (2): 384–90. PMID 1427854. doi:10.1016/S0888-7543(05)80230-7.
• Oikawa S, Inuzuka C, Kuroki M, et al. A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains.. J. Biol. Chem. 1991, 266 (13): 7995–8001. PMID 2022629. doi:10.1016/S0021-9258(18)92930-3 .
• Berling B, Kolbinger F, Grunert F, et al. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow.. Cancer Res. 1990, 50 (20): 6534–9. PMID 2208113.
• Arakawa F, Kuroki M, Misumi Y, et al. Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family.. Biochem. Biophys. Res. Commun. 1990, 166 (3): 1063–71. PMID 2306228. doi:10.1016/0006-291X(90)90975-S.
• Eades-Perner AM, Thompson J, van der Putten H, Zimmermann W. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes.. Blood. 1998, 91 (2): 663–72. PMID 9427723. doi:10.1182/blood.V91.2.663 .
• Torsteinsdóttir I, Arvidson NG, Hällgren R, Håkansson L. Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids.. Scand. J. Immunol. 1999, 50 (4): 433–9. PMID 10520185. S2CID 5692060. doi:10.1046/j.1365-3083.1999.00602.x.
• Oikawa S, Sugiyama M, Kuroki M, et al. Extracellular N-domain alone can mediate specific heterophilic adhesion between members of the carcinoembryonic antigen family, CEACAM6 and CEACAM8.. Biochem. Biophys. Res. Commun. 2001, 278 (3): 564–8. PMID 11095950. doi:10.1006/bbrc.2000.3858.
• Singer BB, Scheffrahn I, Heymann R, et al. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes.. J. Immunol. 2002, 168 (10): 5139–46. PMID 11994468. doi:10.4049/jimmunol.168.10.5139 .
• Zhao L, Xu S, Peterson C, et al. Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes.. J. Immunol. Methods. 2002, 270 (1): 27–35. PMID 12379336. doi:10.1016/s0022-1759(02)00215-6.
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
• Grimwood J, Gordon LA, Olsen A, et al. The DNA sequence and biology of human chromosome 19.. Nature. 2004, 428 (6982): 529–35. Bibcode:2004Natur.428..529G. PMID 15057824. doi:10.1038/nature02399 .
• Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
• Ramachandran P, Boontheung P, Xie Y, et al. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.. J. Proteome Res. 2006, 5 (6): 1493–503. PMID 16740002. doi:10.1021/pr050492k.

外部連結

• 醫學主題詞表（MeSH）：CEACAM8+protein,+human
• Human CEACAM8 genome location and CEACAM8 gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.
• PDBe-KB （頁面存檔備份，存於互聯網檔案館） provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8)

CD66b引用了美國國家醫學圖書館提供的數據，這些數據屬於公共領域。