黃體生成素β亞基

黃體生成素β亞基（英語：Luteinizing hormone subunit beta 或 lutropin subunit beta ）是一種由人類基因LHB 編碼的蛋白質^[1][2]。

Luteinizing hormone beta polypeptide 黃體生成素β多肽
有效結構 PDB 直系同源檢索：PDBe, RCSB PDB查詢代碼列表 1M92
標識
代號	LHB; CGB4; LSH-B; hLHB
擴展標識	遺傳學：152780 鼠基因：96782 同源基因：81806 GeneCards: LHB Gene
基因本體論描述 分子功能 · receptor binding · hormone activity 細胞成分 · extracellular region 生物過程 · progesterone biosynthetic process · signal transduction · cell-cell signaling · male gonad development · peptide hormone processing · cellular protein metabolic process Sources: Amigo / QuickGO
RNA表達模式
更多表達數據
直系同源體
物種	人類	小鼠
Entrez	3972	16866
Ensembl	ENSG00000104826	ENSMUSG00000038194
UniProt	P01229	G3X9G6
mRNA序列	NM_000894	NM_008497
蛋白序列	NP_000885	NP_032523
基因位置	Chr 19: 49.52 – 49.52 Mb	Chr 7: 45.42 – 45.42 Mb
PubMed查詢	[1]	[2]
閱 論 編

基因

該基因位於19號染色體q13.3，編碼黃體生成素的β亞基^[2]。而在馬科動物中，黃體生成素的β亞基和絨毛膜促性腺激素的β亞基是由一個基因編碼的^[3]。

功能

臨床意義

參考文獻

1. Sairam MR, Li CH. Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. Biochim Biophys Acta. Feb 1976, 412 (1): 70–81. PMID 1191677.
2. Entrez Gene: LHB luteinizing hormone beta polypeptide.
3. Sherman GB, Wolfe MW, Farmerie TA, Clay CM, Threadgill DS, Sharp DC, Nilson JH. A single gene encodes the beta-subunits of equine luteinizing hormone and chorionic gonadotropin. Mol. Endocrinol. June 1992, 6 (6): 951–9. PMID 1379674. doi:10.1210/me.6.6.951.

延伸閱讀

• Keutmann HT, Hua QX, Weiss MA. Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy. Mol. Endocrinol. 1992, 6 (6): 904–13. PMID 1495492. doi:10.1210/me.6.6.904.
• Weiss J, Axelrod L, Whitcomb RW; et al. Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone. N. Engl. J. Med. 1992, 326 (3): 179–83. PMID 1727547. doi:10.1056/NEJM199201163260306. 引文格式1維護：顯式使用等標籤 (link)
• Weisshaar G, Hiyama J, Renwick AG, Nimtz M. NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. Eur. J. Biochem. 1991, 195 (1): 257–68. PMID 1991473. doi:10.1111/j.1432-1033.1991.tb15702.x.
• Jameson JL, Lindell CM, Habener JF. Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. DNA. 1986, 5 (3): 227–34. PMID 2424697. doi:10.1089/dna.1986.5.227.
• Keutmann HT, Charlesworth MC, Mason KA; et al. A receptor-binding region in human choriogonadotropin/lutropin beta subunit. Proc. Natl. Acad. Sci. U.S.A. 1987, 84 (7): 2038–42. PMC 304579 . PMID 3470775. doi:10.1073/pnas.84.7.2038. 引文格式1維護：顯式使用等標籤 (link)
• Shome B, Parlow AF. The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH). J. Clin. Endocrinol. Metab. 1973, 36 (3): 618–21. PMID 4685398. doi:10.1210/jcem-36-3-618.
• Closset J, Hennen G, Lequin RM. Human luteinizing hormone. The amino acid sequence of the subunit. FEBS Lett. 1973, 29 (2): 97–100. PMID 4719207. doi:10.1016/0014-5793(73)80534-4.
• Talmadge K, Vamvakopoulos NC, Fiddes JC. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. Nature. 1984, 307 (5946): 37–40. PMID 6690982. doi:10.1038/307037a0.
• Beitins IZ, Axelrod L, Ostrea T; et al. Hypogonadism in a male with an immunologically active, biologically inactive luteinizing hormone: characterization of the abnormal hormone. J. Clin. Endocrinol. Metab. 1981, 52 (6): 1143–9. PMID 6785294. doi:10.1210/jcem-52-6-1143. 引文格式1維護：顯式使用等標籤 (link)
• Berger P, Kranewitter W, Madersbacher S; et al. Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis. FEBS Lett. 1994, 343 (3): 229–33. PMID 7513655. doi:10.1016/0014-5793(94)80561-X. 引文格式1維護：顯式使用等標籤 (link)
• Keutmann HT, Rubin DA. A subunit interaction site in human luteinizing hormone: identification by photoaffinity cross-linking. Endocrinology. 1993, 132 (3): 1305–12. PMID 7679977. doi:10.1210/en.132.3.1305.
• Herrlich A, Kühn B, Grosse R; et al. Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. J. Biol. Chem. 1996, 271 (28): 16764–72. PMID 8663226. doi:10.1074/jbc.271.28.16764. 引文格式1維護：顯式使用等標籤 (link)
• Muyan M, Furuhashi M, Sugahara T, Boime I. The carboxy-terminal region of the beta-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers. Mol. Endocrinol. 1997, 10 (12): 1678–87. PMID 8961276. doi:10.1210/me.10.12.1678.
• Roy AC, Liao WX, Chen Y; et al. Identification of seven novel mutations in LH beta-subunit gene by SSCP. Mol. Cell. Biochem. 1997, 165 (2): 151–3. PMID 8979264. 引文格式1維護：顯式使用等標籤 (link)
• Liao WX, Roy AC, Chan C; et al. A new molecular variant of luteinizing hormone associated with female infertility. Fertil. Steril. 1998, 69 (1): 102–6. PMID 9457942. doi:10.1016/S0015-0282(97)00445-7. 引文格式1維護：顯式使用等標籤 (link)
• O'Connor JF, Kovalevskaya G, Birken S; et al. The expression of the urinary forms of human luteinizing hormone beta fragment in various populations as assessed by a specific immunoradiometric assay. Hum. Reprod. 1998, 13 (4): 826–35. PMID 9619532. doi:10.1093/humrep/13.4.826. 引文格式1維護：顯式使用等標籤 (link)
• Takahashi K, Kurioka H, Ozaki T; et al. Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients. Hum. Reprod. 1999, 13 (12): 3338–44. PMID 9886510. doi:10.1093/humrep/13.12.3338. 引文格式1維護：顯式使用等標籤 (link)
• Elter K, Erel CT, Cine N; et al. Role of the mutations Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome. Fertil. Steril. 1999, 71 (3): 425–30. PMID 10065776. doi:10.1016/S0015-0282(98)00491-9. 引文格式1維護：顯式使用等標籤 (link)
• Jiang M, Pakarinen P, Zhang FP; et al. A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence. Hum. Mol. Genet. 1999, 8 (11): 2037–46. PMID 10484773. doi:10.1093/hmg/8.11.2037. 引文格式1維護：顯式使用等標籤 (link)