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崔文升初為明神宗鄭貴妃宮中內侍太監。明光宗即位，升任司禮監秉筆太監，掌管御藥房。光宗得病，他進大黃藥，於是病情加劇，不能視朝。外廷都說崔文升受貴妃指派，有異謀。給事中楊漣以為是崔文升誤用伐藥。明光宗後來服用鴻臚寺丞李可灼進獻的紅丸，駕崩。於是廷議論罪，將他貶謫南京。明熹宗天啟年間，魏忠賢起用崔文升為總督漕運兼管河道。明思宗即位，召還北京，不久被御史吳煥彈劾，他和同黨在宮門外號哭，明思宗大怒，將他和這些同黨杖責一百，斥充南京孝陵淨軍。
- 《明史》卷305 宦官列傳
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