Neuro-2a

Neuro-2a是快速生長的小鼠神經母細胞瘤細胞系^[1]。Neuro-2a細胞目前已被用於研究神經突的生長^[1]、神經毒性^[2]、阿茲海默症^[3]、哺乳動物細胞系的非對稱性細胞分裂（英語：Asymmetric cell division）^[4]、腺病毒轉導及狂犬病的診斷。

特徵

Neuro-2a細胞起源於小鼠，具有神經元和變形蟲幹細胞的形態，可以根據環境因素進行細胞分化，而已分化的細胞具有神經元的許多特性，例如神經纖維絲（英語：Neurofilament）。這些細胞可能因經過多次傳代而對毒素的反應不同於活生物體內的神經元細胞^[2]。Neuro-2a細胞合成大量的微管，因此容易受到單純皰疹病毒和脊髓灰質炎病毒等的感染，這些病毒會改變細胞的形態和生理學。

參考資料

[1]
Salto, R; Vílchez, JD; Girón, MD; Cabrera, E; Campos, N; Manzano, M; Rueda, R; López-Pedrosa, JM. β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells.. PloS one. 2015, 10 (8): e0135614 [2020-01-06]. PMID 26267903. doi:10.1371/journal.pone.0135614.^{[永久失效連結]}
[2]
LePage, KT; Dickey, RW; Gerwick, WH; Jester, EL; Murray, TF. On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies.. Critical reviews in neurobiology. 2005, 17 (1): 27–50 [2020-01-06]. PMID 16307526. doi:10.1615/critrevneurobiol.v17.i1.20.^{[永久失效連結]}
[3]
Provost, P. Interpretation and applicability of microRNA data to the context of Alzheimer's and age-related diseases.. Aging. 2010-03-31, 2 (3): 166–9 [2020-01-06]. PMID 20375468. doi:10.18632/aging.100131.^{[永久失效連結]}
[4]
Ogrodnik, M; Salmonowicz, H; Brown, R; Turkowska, J; Średniawa, W; Pattabiraman, S; Amen, T; Abraham, AC; Eichler, N; Lyakhovetsky, R; Kaganovich, D. Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin.. Proceedings of the National Academy of Sciences of the United States of America. 2014-06-03, 111 (22): 8049–54 [2020-01-06]. PMID 24843142. doi:10.1073/pnas.1324035111.^{[永久失效連結]}

外部連結

N2a at ATCC (CCL-131)（頁面存檔備份，存於互聯網檔案館）
N2a at ECACC (89121404)（頁面存檔備份，存於互聯網檔案館）
Cellosaurus entry for N2a（頁面存檔備份，存於互聯網檔案館）

[a-1] [1]
Salto, R; Vílchez, JD; Girón, MD; Cabrera, E; Campos, N; Manzano, M; Rueda, R; López-Pedrosa, JM. β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells.. PloS one. 2015, 10 (8): e0135614 [2020-01-06]. PMID 26267903. doi:10.1371/journal.pone.0135614.^{[永久失效連結]}

[b-2] [2]
LePage, KT; Dickey, RW; Gerwick, WH; Jester, EL; Murray, TF. On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies.. Critical reviews in neurobiology. 2005, 17 (1): 27–50 [2020-01-06]. PMID 16307526. doi:10.1615/critrevneurobiol.v17.i1.20.^{[永久失效連結]}

[3] [3]
Provost, P. Interpretation and applicability of microRNA data to the context of Alzheimer's and age-related diseases.. Aging. 2010-03-31, 2 (3): 166–9 [2020-01-06]. PMID 20375468. doi:10.18632/aging.100131.^{[永久失效連結]}

[4] [4]
Ogrodnik, M; Salmonowicz, H; Brown, R; Turkowska, J; Średniawa, W; Pattabiraman, S; Amen, T; Abraham, AC; Eichler, N; Lyakhovetsky, R; Kaganovich, D. Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin.. Proceedings of the National Academy of Sciences of the United States of America. 2014-06-03, 111 (22): 8049–54 [2020-01-06]. PMID 24843142. doi:10.1073/pnas.1324035111.^{[永久失效連結]}

[1]

[2]

[3]

[4]