蛋白酪氨酸磷酸酶C型受體

蛋白酪氨酸磷酸酶C型受體（英語：Protein tyrosine phosphatase, receptor type, C，縮寫：PTPRC）是一個由PTPRC人類基因編碼的酶^[6] 蛋白酪氨酸磷酸酶C型受體又叫做45號分化簇抗原，以前曾叫白細胞常見抗原（英語：leukocyte common antigen，縮寫：LCA）。^[7]

蛋白酪氨酸磷酸酶C型受體
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 1YGU、​1YGR、​5FMV、​5FN6、​5FN7
識別號
別名	PTPRC；, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
外部ID	OMIM：151460 MGI：97810 HomoloGene：2126 GeneCards：PTPRC
相關疾病
潰瘍性結腸炎[1]
基因位置（人類） 染色體 1號染色體[2] 基因座 1q31.3-q32.1 起始 198,638,457 bp[2] 終止 198,757,476 bp[2]
基因位置（小鼠） 染色體 小鼠1號染色體[3] 基因座 1 E4|1 60.73 cM 起始 137,990,599 bp[3] 終止 138,103,446 bp[3]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • phosphoprotein phosphatase activity • phosphatase activity • 血漿蛋白結合 • transmembrane receptor protein tyrosine phosphatase activity • protein kinase binding • 水解酶活性 • protein tyrosine phosphatase activity 細胞組分 • integral component of membrane • 膜 • 粘着斑 • 細胞膜 • integral component of plasma membrane • cell surface • 脂筏模型 • 外排體 • external side of plasma membrane • secretory granule membrane 生物學過程 • B cell receptor signaling pathway • cell cycle phase transition • release of sequestered calcium ion into cytosol • negative regulation of protein kinase activity • bone marrow development • stem cell development • 蛋白質去磷酸化 • negative regulation of cytokine-mediated signaling pathway • positive regulation of hematopoietic stem cell migration • regulation of cell cycle • negative regulation of cell adhesion involved in substrate-bound cell migration • negative regulation of T cell mediated cytotoxicity • cell surface receptor signaling pathway • B cell proliferation • T cell differentiation • positive regulation of B cell proliferation • defense response to virus • positive regulation of T cell proliferation • hematopoietic progenitor cell differentiation • positive regulation of antigen receptor-mediated signaling pathway • T cell receptor signaling pathway • positive regulation of stem cell proliferation • 去磷酸化 • positive regulation of protein kinase activity • peptidyl-tyrosine dephosphorylation • neutrophil degranulation Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	5788	19264
Ensembl	ENSG00000081237 ​ENSG00000262418	ENSMUSG00000026395
UniProt	P08575	P06800
mRNA​序列	​NM_001267798 ​NM_002838 ​NM_080921 ​NM_080922	NM_001111316 ​NM_001268286 ​NM_011210
蛋白序列	NP_001254727 ​NP_002829 ​NP_563578 NP_563578.2 NP_002829.3	NP_001104786 ​NP_001255215 ​NP_035340
基因位置​（UCSC）	Chr 1: 198.64 – 198.76 Mb	Chr 1: 137.99 – 138.1 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

參考文獻

1. 與蛋白酪氨酸磷酸酶C型受體相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000081237、​ENSG00000262418 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000026395 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc. Natl. Acad. Sci. U.S.A. September 1990, 87 (18): 7000–4 [2019-05-01]. PMC 54670 . PMID 2169617. doi:10.1073/pnas.87.18.7000. （原始內容存檔於2019-10-17）.
7. Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C. （原始內容存檔於2010-12-05）.