靶向給藥(英文:Targeted drug delivery),或稱靶向藥物遞送或智能藥物遞送,[1]是一種以增加身體某部位藥物濃度的方式向患者進行藥物遞送的方法。當代靶向給藥的遞送方式主要建立在以納米醫學的基礎之上,採用納米粒子介導的藥物遞送系統,以克服傳統藥物遞送方式的諸多不足。納米顆粒憑藉自身的靶向能力,將載有藥物的製劑傳送至患者體內的特定病灶,以避免藥物與健康組織起作用從而減少不良反應。靶向給藥系統的目標是:延長藥物作用時間、將藥物控制在局部範圍、將藥物靶向遞送至病灶,並維持藥物與病灶組織的相互作用。傳統的藥物遞送系統是指:藥物通過生物膜的吸收,而「靶向釋放系統」(Targeted release system )是以特殊劑型釋放藥物。靶向釋放系統優勢在於:減少患者服藥頻率、更具一致性的藥物作用、減輕藥物副作用和降低體循環中藥物濃度波動。現階段該系統的劣勢在於:成本較高、生產難度較大、劑量調整能力降低。
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