核苷類逆轉錄酶抑制劑(英語:Nucleoside Reverse Transcriptase Inhibitors,簡稱NRTIs),是合成HIV的DNA逆轉錄酶底物去氧核苷酸的類似物,在體內轉化成活性的三磷酸核苷衍生物,與天然的三磷酸去氧核苷競爭性與HIV逆轉錄酶(RT)結合,抑制RT的作用,阻礙前病毒的合成。
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