膽固醇側鏈裂解酶

膽固醇側鏈裂解酶（英語：Cholesterol side-chain cleavage enzyme，CYP11A1或P450scc，其中「scc」是「side-chain 側鏈」「cleavage 裂解」的縮寫）是一種將膽固醇轉化為孕烯醇酮的線粒體酶。這是所有哺乳動物中由膽固醇生成各種甾類激素的第一步反應^[7]。

膽固醇 + 3 NADPH + 3 H⁺ + 3 O₂ ⇄ 孕烯醇酮 + 4-甲基戊醛 + 3 NADP⁺ + 3 H₂O

膽固醇側鏈裂解酶
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 3NA1、​3N9Y、​3N9Z、​3NA0
識別號
別名	CYP11A1；, CYP11A, CYPXIA1, P450SCC, cytochrome P450 family 11 subfamily A member 1
外部ID	OMIM：118485 MGI：88582 HomoloGene：37347 GeneCards：CYP11A1
相關疾病
congenital adrenal insufficiency[1]
為以下藥物的標靶
米托坦、​氨魯米特[2]
基因位置（人類） 染色體 15號染色體[3] 基因座 15q24.1 起始 74,337,759 bp[3] 終止 74,367,646 bp[3]
基因位置（小鼠） 染色體 小鼠9號染色體[4] 基因座 9 B|9 31.63 cM 起始 57,913,694 bp[4] 終止 57,934,306 bp[4]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • iron ion binding • 金屬離子結合 • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • cholesterol monooxygenase (side-chain-cleaving) activity • 血漿蛋白結合 細胞組分 • 膜 • 線粒體基質 • 線粒體 • mitochondrial inner membrane 生物學過程 • vitamin D metabolic process • C21-steroid hormone metabolic process • 脂質代謝 • cholesterol metabolic process • C21-steroid hormone biosynthetic process • sterol metabolic process • steroid biosynthetic process • steroid metabolic process • glucocorticoid biosynthetic process • cellular response to peptide hormone stimulus • cortisol metabolic process Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	1583	13070
Ensembl	ENSG00000140459 ​ENSG00000288362	ENSMUSG00000032323
UniProt	P05108	Q9QZ82
mRNA​序列	NM_001099773 ​NM_000781	NM_019779 ​NM_001346787
蛋白序列	NP_000772 ​NP_001093243	NP_001333716 ​NP_062753
基因位置​（UCSC）	Chr 15: 74.34 – 74.37 Mb	Chr 9: 57.91 – 57.93 Mb
PubMed​查找	[5]	[6]
維基數據
檢視/編輯人類 檢視/編輯小鼠

P450scc 是細胞色素P450氧化酶超家族的一員（家族11亞家族A多肽1），基因名為 CYP11A1^[8]。

另見

• 類固醇生成酶
• 細胞色素P450

參考文獻

1. 與胆固醇侧链裂解酶相關的疾病；在維基數據上查看/編輯參考.
2. 對胆固醇侧链裂解酶起作用的藥物；在維基數據上查看/編輯參考.
3. GRCh38: Ensembl release 89: ENSG00000140459、​ENSG00000288362 - Ensembl, May 2017
4. GRCm38: Ensembl release 89: ENSMUSG00000032323 - Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. Hanukoglu I. Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis. The Journal of Steroid Biochemistry and Molecular Biology. December 1992, 43 (8): 779–804. PMID 22217824. doi:10.1016/0960-0760(92)90307-5.
8. Entrez Gene: CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1.

延伸閱讀

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