TATA結合蛋白

TATA結合蛋白質（英語：TATA-binding protein，TBP）是一種通用轉錄因子，具體結合於DNA序列上的TATA盒。TATA盒位於真核基因的轉錄起始位點上游約25個bp，屬於啟動子區^[6]。TBP可以和各個TBP相關因子共同組成通用轉錄因子TF_IID,再進一步組成RNA聚合酶Ⅱ的轉錄起始複合物^[7]。

TATA結合蛋白
已知的結構 PDB 直系同源搜尋: PDBe RCSB PDBID列表 1TGH、​1C9B、​1JFI、​1NVP、​4ROC、​4ROE、​4ROD、​5IY9、​5IYA、​5FUR、​5IYC、​5IYB、​5IY7、​5IY8、​5IYD、​5IY6
識別號
別名	TBP；, GTF2D, GTF2D1, HDL4, SCA17, TFIID, TATA-box binding protein, TATA-binding protein, TBP1
外部ID	OMIM：600075 MGI：101838 HomoloGene：2404 GeneCards：TBP
相關疾病
spinocerebellar ataxia type 17[1]
基因位置（人類） 染色體 6號染色體[2] 基因座 6q27 起始 170,554,302 bp[2] 終止 170,572,870 bp[2]
基因位置（小鼠） 染色體 小鼠17號染色體[3] 基因座 17 A2|17 8.95 cM 起始 15,720,150 bp[3] 終止 15,748,641 bp[3]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • DNA結合 • DNA結合轉錄因子活性 • 轉錄因子結合 • RNA polymerase II cis-regulatory region sequence-specific DNA binding • 血漿蛋白結合 • 酶結合 • TFIIB-class transcription factor binding • aryl hydrocarbon receptor binding • 核心啟動子近端區域序列特異性DNA結合 • DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase III general transcription initiation factor activity • RNA polymerase II general transcription initiation factor activity • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase III transcription regulatory region sequence-specific DNA binding 細胞組分 • 細胞質 • transcription factor TFIID complex • male pronucleus • 雌原核 • 核質 • transcription factor TFIIA complex • pronucleus • 細胞核 • transcription preinitiation complex • 大分子複合體 • transcription factor TFIIIB complex • 轉錄調節複合物 生物學過程 • termination of RNA polymerase I transcription • epigenetic maintenance of chromatin in transcription-competent conformation • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase I promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • 精子發生 • DNA-templated transcription, initiation • transcription initiation from RNA polymerase II promoter • snRNA transcription by RNA polymerase II • regulation of signal transduction by p53 class mediator • viral process • regulation of transcription by RNA polymerase III • transcription by RNA polymerase II • transcription by RNA polymerase III • RNA polymerase II preinitiation complex assembly • regulation of transcription by RNA polymerase II • RNA polymerase III preinitiation complex assembly • transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	6908	21374
Ensembl	ENSG00000112592	ENSMUSG00000014767
UniProt	P20226	P29037
mRNA​序列	NM_003194 ​NM_001172085	NM_013684
蛋白序列	NP_001165556 ​NP_003185	NP_038712
基因位置​（UCSC）	Chr 6: 170.55 – 170.57 Mb	Chr 17: 15.72 – 15.75 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

TBP
crystal structure of a yeast brf1-tbp-dna ternary complex
鑑定
標誌	TBP
Pfam	PF00352（舊版）
Pfam宗系	CL0407（舊版）
InterPro（英語：InterPro）	IPR000814
PROSITE（英語：PROSITE）	PDOC00303
SCOP（英語：Structural Classification of Proteins）	1tbp / SUPFAM
現有可用的蛋白結構： Pfam 結構（舊版） / ECOD PDB RCSB PDB; PDBe; PDBj PDBsum（英語：PDBsum） 結構概要

蛋白質的相互作用

TATA結合蛋白與下列蛋白質進行互作：

• BRF1,^[8][9]
• BTAF1,^[10][11]
• C-Fos,^[12]
• C-jun,^[13]
• EDF1,^[14][15][16]
• GTF2B (TFIIB),^[17][18]
• GTF2A1 (TFIIA subunit 1),^{[17][19][20][21]}
• GTF2F1 (TFIIF subunit 1)^[10][22][23]
• GTF2H4 (TFIIH subunit 4),^[10]
• Mdm2,^[24][24][25]
• MSX1,^[26][27][28]
• NFYB,^[29]
• P53,^[30][31]
• PAX6,^[31]
• POLR2A,^[10]
• POU2F1,^[32]
• RELA,^[33][34]
• NR2B1,^[35]
• TAF1,^{[29][36][37][38]}
• TAF4,^[39]
• TAF5,^[29][37][40]
• TAF6,^[29][37][39]
• TAF7,^[29][39]
• TAF9.^[29][41]
• TAF10,^[29][37]
• TAF11,^[29][42][43]
• TAF13,^[42]
• TAF15.^[44]

參考文獻

1. 與TATA结合蛋白相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000112592 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000014767 - Ensembl, May 2017
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5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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外部連結

• GeneReviews/NCBI/國家衛生研究院/大學進入脊髓小腦失調類型17（頁面存檔備份，存於互聯網檔案館）
• 交互式TBP結構在梅西。ac.新西蘭
• 每月PDB分子主題TATA-binding protein
• 醫學主題詞表（MeSH）：TATA-Box+Binding+Protein
• FactorBook TBP