STAT3

信號轉導及轉錄激活蛋白3（英語：Signal transducer and activator of transcription 3，STAT3）是一種由人類基因STAT3 編碼的轉錄因子^[1]。

Signal transducer and activator of transcription 3 (acute-phase response factor) 信號轉導及轉錄激活蛋白3（急性期反應因子）
PDB rendering based on 1bg1.
有效結構 PDB 直系同源檢索：PDBe, RCSB PDB查詢代碼列表 1bg1
標識
代號	STAT3; APRF; HIES
擴展標識	遺傳學：102582 鼠基因：103038 同源基因：7960 ChEMBL: 4026 GeneCards: STAT3 Gene
基因本體論描述 分子功能 · RNA polymerase II repressing transcription factor binding · DNA binding · sequence-specific DNA binding transcription factor activity · signal transducer activity · ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity · calcium ion binding · protein binding · transcription factor binding · protein kinase binding · CCR5 chemokine receptor binding · glucocorticoid receptor binding · sequence-specific DNA binding · transcription regulatory region DNA binding · protein dimerization activity 細胞成分 · nucleus · nucleoplasm · nucleolus · cytoplasm · cytosol · plasma membrane 生物過程 · negative regulation of transcription from RNA polymerase II promoter · temperature homeostasis · eye photoreceptor cell differentiation · regulation of transcription, DNA-dependent · regulation of transcription from RNA polymerase II promoter · protein import into nucleus · cellular component movement · acute-phase response · signal transduction · JAK-STAT cascade · nervous system development · cell proliferation · virus-host interaction · cytokine-mediated signaling pathway · stem cell maintenance · sexual reproduction · intracellular receptor signaling pathway · response to estradiol stimulus · cellular response to hormone stimulus · regulation of multicellular organism growth · response to drug · glucose homeostasis · eating behavior · response to ethanol · positive regulation of Notch signaling pathway · positive regulation of transcription, DNA-dependent · positive regulation of transcription from RNA polymerase II promoter · neurotrophin TRK receptor signaling pathway · astrocyte differentiation · radial glial cell differentiation · growth hormone receptor signaling pathway · JAK-STAT cascade involved in growth hormone signaling pathway · interleukin-6-mediated signaling pathway Sources: Amigo / QuickGO
RNA表達模式
更多表達數據
直系同源體
物種	人類	小鼠
Entrez	6774	20848
Ensembl	ENSG00000168610	ENSMUSG00000004040
UniProt	P40763	P42227
mRNA序列	NM_003150	NM_011486
蛋白序列	NP_003141	NP_035616
基因位置	Chr 17: 40.47 – 40.54 Mb	Chr 11: 100.89 – 100.94 Mb
PubMed查詢	[1]	[2]
閱 論 編

功能

STAT3是STAT蛋白家族的成員。受到細胞因子和生長因子的調節，STAT3被受體相關的Janus激酶（JAK）磷酸化，形成同源或異源二聚體，並轉移到細胞核，在那裏它們起轉錄激活劑的作用。具體而言，干擾素，表皮生長因子（EGF），白細胞介素（IL-5和IL-6）等配體作用於受體，導致酪氨酸705磷酸化後，STAT3被激活。此外，STAT3可能通過絲裂原活化蛋白激酶（MAPK）^[2]和c-src非受體酪氨酸激酶磷酸化絲氨酸727而激活。^[3][4]STAT3介導響應細胞刺激的各種基因的表達，因此在許多細胞過程如細胞生長和細胞凋亡中起關鍵作用。^[5]

當原腸胚形成開始時，STAT3缺陷的小鼠胚胎不能在胚胎發育第7天以後發育。^[6]看來在這些發育的早期階段，STAT3激活是胚胎幹細胞（ESC）自我更新所必需的。事實上，如果STAT3通過其他方式被激活，LIF可以被省略，該LIF被提供給小鼠ESC培養物以保持其未分化狀態。^[7]

STAT3對於TH17輔助性T細胞的分化至關重要，TH17輔助性T細胞已涉及多種自體免疫性疾病。^[8]在病毒感染期間，缺乏T細胞中STAT3的小鼠顯示產生T-濾泡輔助（Tfh）細胞的能力受損，並且不能維持基於抗體的免疫性。^[9]

臨床意義

在癌症中的雙重作用

相互作用

STAT3能與下列蛋白質發生交互作用：

• AR^[10][11]
• ELP2^[12]
• EP300^[13]
• EGFR^[14][15]
• HIF1A^[16]
• JAK1^[10][17]
• JUN^[18]
• KHDRBS1^[19]
• MTOR^[20][21]
• MYOD1^[22]
• NDUFA13^[23]
• NFKB1^[24]
• NR3C1^[25][26]
• NCOA1^[27]
• PML^[28]
• RAC1^[29]
• RELA^[24]
• RET^[14][30][31]
• RPA2^[32]
• STAT1^[17][33][34]
• Src^[35]
• TRIP10^[36]

參考文獻

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延伸閱讀

• Hoey T, Grusby MJ. STATs as mediators of cytokine-induced responses. Adv. Immunol. Advances in Immunology. 1999, 71: 145–162. ISBN 978-0-12-022471-5. PMID 9917912. doi:10.1016/S0065-2776(08)60401-0.
• Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002, 285 (1–2): 1–24. PMID 12039028. doi:10.1016/S0378-1119(02)00398-0.
• Joseph AM, Kumar M, Mitra D. Nef: "necessary and enforcing factor" in HIV infection. Curr. HIV Res. 2005, 3 (1): 87–94. PMID 15638726. doi:10.2174/1570162052773013.
• Inghirami G; Chiarle R; Simmons WJ; et al. New and old functions of STAT3: a pivotal target for individualized treatment of cancer. Cell Cycle. 2006, 4 (9): 1131–3. PMID 16082218.
• Leeman RJ, Lui VW, Grandis JR. STAT3 as a therapeutic target in head and neck cancer. Expert opinion on biological therapy. 2006, 6 (3): 231–241. PMID 16503733. doi:10.1517/14712598.6.3.231.
• Aggarwal BB; Sethi G; Ahn KS; et al. Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. Ann. N. Y. Acad. Sci. 2007, 1091: 151–169. PMID 17341611. doi:10.1196/annals.1378.063.

外部連結

• FactorBook STAT3