SOX9位於17號人類染色體的基因 / 維基百科,自由的 encyclopedia SOX9(英語:Transcription factor SOX-9)是一種轉錄因子,由人類基因Sox9編碼,是塞爾托利氏細胞等細胞的標誌物[5][6]。 Quick Facts SOX9, 已知的結構 ...SOX9已知的結構PDB直系同源搜尋: PDBe RCSB PDBID列表4EUW識別號別名SOX9;, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 9外部IDOMIM:608160 MGI:98371 HomoloGene:294 GeneCards:SOX9 基因位置(人類)染色體17號染色體[1]基因座17q24.3起始72,121,020 bp[1]終止72,126,416 bp[1]基因位置(小鼠)染色體小鼠11號染色體[2]基因座11 E2|11 77.27 cM起始112,673,050 bp[2]終止112,678,586 bp[2]RNA表達模式查閱更多表達數據基因本體分子功能• DNA結合轉錄因子活性• DNA-binding transcription activator activity, RNA polymerase II-specific• core promoter sequence-specific DNA binding• 蛋白激酶活性• protein kinase A catalytic subunit binding• beta-catenin binding• pre-mRNA intronic binding• chromatin binding• 血漿蛋白結合• DNA結合• sequence-specific DNA binding• transcription cis-regulatory region binding• bHLH transcription factor binding• 核心啟動子近端區域序列特異性DNA結合• protein heterodimerization activity• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding• DNA-binding transcription factor activity, RNA polymerase II-specific• RNA polymerase II cis-regulatory region sequence-specific DNA binding細胞組分• 細胞核• 轉錄調節複合物• 核質• 大分子複合體生物學過程• 骨骼系統的發生• cellular response to retinoic acid• bronchus cartilage development• positive regulation of protein phosphorylation• heart valve development• limb bud formation• positive regulation of protein catabolic process• regulation of transcription by RNA polymerase II• ureter morphogenesis• negative regulation of immune system process• chondrocyte development• positive regulation of cell proliferation involved in heart morphogenesis• oligodendrocyte differentiation• chondrocyte hypertrophy• prostate gland development• lung smooth muscle development• 乳腺發育• negative regulation of ossification• negative regulation of photoreceptor cell differentiation• cellular response to mechanical stimulus• intrahepatic bile duct development• regulation of cell adhesion• negative regulation of chondrocyte differentiation• positive regulation of mesenchymal cell proliferation• astrocyte fate commitment• positive regulation of chondrocyte differentiation• 精子發生• prostate gland morphogenesis• negative regulation of epithelial cell proliferation• lung epithelial cell differentiation• chondrocyte differentiation involved in endochondral bone morphogenesis• negative regulation of canonical Wnt signaling pathway• endocrine pancreas development• negative regulation of cell population proliferation• regulation of apoptotic process• cellular response to transforming growth factor beta stimulus• negative regulation of mesenchymal cell apoptotic process• 染色體重建• negative regulation of myoblast differentiation• positive regulation of branching involved in ureteric bud morphogenesis• cell fate commitment• regulation of transcription, DNA-templated• epidermal growth factor receptor signaling pathway• 成骨作用• regulation of cell proliferation involved in tissue homeostasis• ureter smooth muscle cell differentiation• ERK1 and ERK2 cascade• notochord development• positive regulation of epithelial cell migration• Sertoli cell differentiation• male sex determination• negative regulation of gene expression• transcription, DNA-templated• metanephric nephron tubule formation• positive regulation of transcription, DNA-templated• 心臟發育• regulation of branching involved in lung morphogenesis• ureter urothelium development• branching involved in ureteric bud morphogenesis• 軟骨生成• Harderian gland development• positive regulation of kidney development• central nervous system development• heart valve formation• positive regulation of cartilage development• tissue homeostasis• metanephric tubule development• negative regulation of biomineral tissue development• endochondral bone morphogenesis• trachea cartilage development• male germ-line sex determination• 淚腺的發生• Notch信號通路• hair follicle development• 細胞分化• 輸尿管的發生• regulation of cell cycle process• male gonad development• positive regulation of epithelial cell proliferation• cell fate specification• intestinal epithelial structure maintenance• positive regulation of extracellular matrix assembly• extracellular matrix organization• negative regulation of apoptotic process• negative regulation of transcription by RNA polymerase II• Sertoli cell development• positive regulation of mesenchymal stem cell differentiation• retina development in camera-type eye• cellular response to interleukin-1• 上皮-間充質轉換• homeostasis of number of cells within a tissue• negative regulation of transcription, DNA-templated• cAMP-mediated signaling• cartilage condensation• positive regulation of male gonad development• nucleosome assembly• negative regulation of bone mineralization• morphogenesis of a branching epithelium• neural crest cell development• Akt/PKB信號通路• somatic stem cell population maintenance• otic vesicle formation• otic vesicle development• endocardial cushion morphogenesis• cellular response to epidermal growth factor stimulus• positive regulation of epithelial cell differentiation• renal vesicle induction• positive regulation of gene expression• regulation of epithelial cell proliferation involved in lung morphogenesis• regulation of cell population proliferation• heart valve morphogenesis• 細胞骨架組織• cochlea morphogenesis• positive regulation of cell population proliferation• epithelial cell proliferation involved in prostatic bud elongation• retinal rod cell differentiation• protein localization to nucleus• regulation of cell differentiation• positive regulation of phosphatidylinositol 3-kinase signaling• cellular response to heparin• negative regulation of epithelial cell differentiation• epithelial tube branching involved in lung morphogenesis• 信號轉導• positive regulation of transcription by RNA polymerase II• negative regulation of pri-miRNA transcription by RNA polymerase II• chondrocyte differentiation• neural crest cell fate specification• cellular response to BMP stimulus• cell-cell adhesion• transcription initiation from RNA polymerase II promoter• protein-containing complex assembly• anterior head development• morphogenesis of an epithelium• aortic valve morphogenesis• 基因調節Sources:Amigo / QuickGO直系同源物種人類小鼠Entrez666220682EnsemblENSG00000125398ENSMUSG00000000567UniProtP48436Q04887mRNA序列NM_000346NM_011448蛋白序列NP_000337NP_035578基因位置(UCSC)Chr 17: 72.12 – 72.13 MbChr 11: 112.67 – 112.68 MbPubMed查找[3][4]維基數據檢視/編輯人類檢視/編輯小鼠Close
SOX9(英語:Transcription factor SOX-9)是一種轉錄因子,由人類基因Sox9編碼,是塞爾托利氏細胞等細胞的標誌物[5][6]。 Quick Facts SOX9, 已知的結構 ...SOX9已知的結構PDB直系同源搜尋: PDBe RCSB PDBID列表4EUW識別號別名SOX9;, CMD1, CMPD1, SRA1, SRXX2, SRXY10, SRY-box 9, SRY-box transcription factor 9外部IDOMIM:608160 MGI:98371 HomoloGene:294 GeneCards:SOX9 基因位置(人類)染色體17號染色體[1]基因座17q24.3起始72,121,020 bp[1]終止72,126,416 bp[1]基因位置(小鼠)染色體小鼠11號染色體[2]基因座11 E2|11 77.27 cM起始112,673,050 bp[2]終止112,678,586 bp[2]RNA表達模式查閱更多表達數據基因本體分子功能• DNA結合轉錄因子活性• DNA-binding transcription activator activity, RNA polymerase II-specific• core promoter sequence-specific DNA binding• 蛋白激酶活性• protein kinase A catalytic subunit binding• beta-catenin binding• pre-mRNA intronic binding• chromatin binding• 血漿蛋白結合• DNA結合• sequence-specific DNA binding• transcription cis-regulatory region binding• bHLH transcription factor binding• 核心啟動子近端區域序列特異性DNA結合• protein heterodimerization activity• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding• DNA-binding transcription factor activity, RNA polymerase II-specific• RNA polymerase II cis-regulatory region sequence-specific DNA binding細胞組分• 細胞核• 轉錄調節複合物• 核質• 大分子複合體生物學過程• 骨骼系統的發生• cellular response to retinoic acid• bronchus cartilage development• positive regulation of protein phosphorylation• heart valve development• limb bud formation• positive regulation of protein catabolic process• regulation of transcription by RNA polymerase II• ureter morphogenesis• negative regulation of immune system process• chondrocyte development• positive regulation of cell proliferation involved in heart morphogenesis• oligodendrocyte differentiation• chondrocyte hypertrophy• prostate gland development• lung smooth muscle development• 乳腺發育• negative regulation of ossification• negative regulation of photoreceptor cell differentiation• cellular response to mechanical stimulus• intrahepatic bile duct development• regulation of cell adhesion• negative regulation of chondrocyte differentiation• positive regulation of mesenchymal cell proliferation• astrocyte fate commitment• positive regulation of chondrocyte differentiation• 精子發生• prostate gland morphogenesis• negative regulation of epithelial cell proliferation• lung epithelial cell differentiation• chondrocyte differentiation involved in endochondral bone morphogenesis• negative regulation of canonical Wnt signaling pathway• endocrine pancreas development• negative regulation of cell population proliferation• regulation of apoptotic process• cellular response to transforming growth factor beta stimulus• negative regulation of mesenchymal cell apoptotic process• 染色體重建• negative regulation of myoblast differentiation• positive regulation of branching involved in ureteric bud morphogenesis• cell fate commitment• regulation of transcription, DNA-templated• epidermal growth factor receptor signaling pathway• 成骨作用• regulation of cell proliferation involved in tissue homeostasis• ureter smooth muscle cell differentiation• ERK1 and ERK2 cascade• notochord development• positive regulation of epithelial cell migration• Sertoli cell differentiation• male sex determination• negative regulation of gene expression• transcription, DNA-templated• metanephric nephron tubule formation• positive regulation of transcription, DNA-templated• 心臟發育• regulation of branching involved in lung morphogenesis• ureter urothelium development• branching involved in ureteric bud morphogenesis• 軟骨生成• Harderian gland development• positive regulation of kidney development• central nervous system development• heart valve formation• positive regulation of cartilage development• tissue homeostasis• metanephric tubule development• negative regulation of biomineral tissue development• endochondral bone morphogenesis• trachea cartilage development• male germ-line sex determination• 淚腺的發生• Notch信號通路• hair follicle development• 細胞分化• 輸尿管的發生• regulation of cell cycle process• male gonad development• positive regulation of epithelial cell proliferation• cell fate specification• intestinal epithelial structure maintenance• positive regulation of extracellular matrix assembly• extracellular matrix organization• negative regulation of apoptotic process• negative regulation of transcription by RNA polymerase II• Sertoli cell development• positive regulation of mesenchymal stem cell differentiation• retina development in camera-type eye• cellular response to interleukin-1• 上皮-間充質轉換• homeostasis of number of cells within a tissue• negative regulation of transcription, DNA-templated• cAMP-mediated signaling• cartilage condensation• positive regulation of male gonad development• nucleosome assembly• negative regulation of bone mineralization• morphogenesis of a branching epithelium• neural crest cell development• Akt/PKB信號通路• somatic stem cell population maintenance• otic vesicle formation• otic vesicle development• endocardial cushion morphogenesis• cellular response to epidermal growth factor stimulus• positive regulation of epithelial cell differentiation• renal vesicle induction• positive regulation of gene expression• regulation of epithelial cell proliferation involved in lung morphogenesis• regulation of cell population proliferation• heart valve morphogenesis• 細胞骨架組織• cochlea morphogenesis• positive regulation of cell population proliferation• epithelial cell proliferation involved in prostatic bud elongation• retinal rod cell differentiation• protein localization to nucleus• regulation of cell differentiation• positive regulation of phosphatidylinositol 3-kinase signaling• cellular response to heparin• negative regulation of epithelial cell differentiation• epithelial tube branching involved in lung morphogenesis• 信號轉導• positive regulation of transcription by RNA polymerase II• negative regulation of pri-miRNA transcription by RNA polymerase II• chondrocyte differentiation• neural crest cell fate specification• cellular response to BMP stimulus• cell-cell adhesion• transcription initiation from RNA polymerase II promoter• protein-containing complex assembly• anterior head development• morphogenesis of an epithelium• aortic valve morphogenesis• 基因調節Sources:Amigo / QuickGO直系同源物種人類小鼠Entrez666220682EnsemblENSG00000125398ENSMUSG00000000567UniProtP48436Q04887mRNA序列NM_000346NM_011448蛋白序列NP_000337NP_035578基因位置(UCSC)Chr 17: 72.12 – 72.13 MbChr 11: 112.67 – 112.68 MbPubMed查找[3][4]維基數據檢視/編輯人類檢視/編輯小鼠Close