蛛毒素受體2

蛛毒素受體2（英語：Latrophilin 2）是一種在人類中由ADGRL2基因編碼的蛋白質。^[5][6]

蛛毒素受體2
識別號
別名	ADGRL2；, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
外部ID	OMIM：607018 MGI：2139714 HomoloGene：22712 GeneCards：ADGRL2
基因位置（人類） 染色體 1號染色體[1] 基因座 1p31.1 起始 81,306,147 bp[1] 終止 81,993,932 bp[1]
基因位置（小鼠） 染色體 小鼠3號染色體[2] 基因座 3|3 H3 起始 148,815,583 bp[2] 終止 148,990,555 bp[2]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • G protein-coupled receptor activity • transmembrane signaling receptor activity • latrotoxin receptor activity • signal transducer activity • carbohydrate binding 細胞組分 • integral component of membrane • 膜 • 胞內 • integral component of plasma membrane • neuron projection 生物學過程 • G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • 信號轉導 • adenylate cyclase-activating G protein-coupled receptor signaling pathway • brain development Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	23266	99633
Ensembl	ENSG00000117114	ENSMUSG00000028184
UniProt	O95490	Q8JZZ7
mRNA​序列	NM_001297704 ​NM_001297705 ​NM_001297706 ​NM_012302 ​NM_001330645 ​NM_001350698 ​NM_001350699 ​NM_001366002 ​NM_001366003 ​NM_001366004 ​NM_001366005 ​NM_001366006 ​NM_001366007 ​NM_001366008 ​NM_001366009 ​NM_001393349 ​NM_001393350 ​NM_001393351 ​NM_001393352 ​NM_001393353 ​NM_001393354	NM_001081298
蛋白序列	NP_001284633 ​NP_001284634 ​NP_001284635 ​NP_001317574 ​NP_036434 ​NP_001337627 ​NP_001337628 ​NP_001352931 ​NP_001352932 ​NP_001352933 ​NP_001352934 ​NP_001352935 ​NP_001352936 ​NP_001352937 ​NP_001352938	NP_001074767 ​NP_001392915 ​NP_001392916 ​NP_001392917 ​NP_001392918 ​NP_001392919 ​NP_001392920 ​NP_001392921 ​NP_001392922 ​NP_001392923 ​NP_001392924 ​NP_001392925 ​NP_001392926 ​NP_001392927 ​NP_001392928 ​NP_001392929 ​NP_001392930 ​NP_001392931 ​NP_001392932 ​NP_001392933 ​NP_001392934 ​NP_001392935 ​NP_001392936 ​NP_001392937 ​NP_001392938 ​NP_001392939 ​NP_001392940 ​NP_001392947 ​NP_001392948
基因位置​（UCSC）	Chr 1: 81.31 – 81.99 Mb	Chr 3: 148.82 – 148.99 Mb
PubMed​查找	[3]	[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

該基因編碼G蛋白偶聯受體（GPCR）的蛛毒素受體亞家族成員。蛛毒素受體可能在細胞黏附和信號轉導中發揮作用。在非人類物種的實驗中，富含半胱氨酸的GPS（G蛋白偶聯受體蛋白水解位點）結構域內的內源性蛋白水解切割產生兩個亞基（一個大的細胞外N末端細胞黏附亞基和一個與GPCR的促胰液素/降鈣素家族具有實質相似性的亞基）非共價結合在細胞膜上。雖然已經描述了幾種轉錄變體，但僅確定了其中一種的生物學有效性。^[6]

參見

• 黏附G蛋白偶聯受體

參考資料

1. GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. White GR, Varley JM, Heighway J. Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. Apr 2000, 1491 (1–3): 75–92. PMID 10760572. doi:10.1016/s0167-4781(00)00020-8.
6. Entrez Gene: LPHN2 latrophilin 2.

延申閱讀

• Südhof TC. alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. Annual Review of Neuroscience. 2001, 24 (1): 933–62. PMID 11520923. doi:10.1146/annurev.neuro.24.1.933.
• Ushkaryov YA, Volynski KE, Ashton AC. The multiple actions of black widow spider toxins and their selective use in neurosecretion studies. Toxicon. Apr 2004, 43 (5): 527–42. PMID 15066411. doi:10.1016/j.toxicon.2004.02.008.
• Bonaldo MF, Lennon G, Soares MB. Normalization and subtraction: two approaches to facilitate gene discovery. Genome Research. Sep 1996, 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791 .
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Research. Oct 1998, 5 (5): 277–86. PMID 9872452. doi:10.1093/dnares/5.5.277 .
• White GR, Varley JM, Heighway J. Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. Oncogene. Dec 1998, 17 (26): 3513–9. PMID 10030676. doi:10.1038/sj.onc.1202487 .
• Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. The Journal of Biological Chemistry. Oct 2000, 275 (42): 32387–90. PMID 10964907. doi:10.1074/jbc.C000490200 .
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. Jul 2004, 84 (1): 23–33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004.
• Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE. Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biology. 2007, 8 (4): R64. PMC 1896007 . PMID 17456239. doi:10.1186/gb-2007-8-4-r64.