甲狀腺激素β受體位於3號人類染色體的基因 / 維基百科,自由的 encyclopedia 甲狀腺激素β受體(TR-β,或THR-β)也稱為核受體亞家族1,A 組,成員2(NR1A2),是一種核受體蛋白,在人類中由THR-β基因編碼。[7][8] Quick Facts 甲狀腺激素β受體, 已知的結構 ...甲狀腺激素β受體已知的結構PDB直系同源搜尋: PDBe RCSB PDBID列表1BSX、1N46、1NAX、1NQ0、1NQ1、1NQ2、1NUO、1Q4X、1R6G、1XZX、1Y0X、2J4A、2NLL、2PIN、3D57、3GWS、3IMY、3JZC、4ZO1識別號別名THRB;, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, TRbeta外部IDOMIM:190160 MGI:98743 HomoloGene:36025 GeneCards:THRB 相關疾病selective pituitary resistance to thyroid hormone、generalized resistance to thyroid hormone[1]為以下藥物的標靶反三碘甲狀腺原氨酸、替拉曲可、三碘甲腺原氨酸、左旋甲狀腺素鈉[2]基因位置(人類)染色體3號染色體[3]基因座3p24.2起始24,117,153 bp[3]終止24,495,756 bp[3]基因位置(小鼠)染色體小鼠14號染色體[4]基因座14|14 A1起始4,431,611 bp[4]終止4,809,435 bp[4]RNA表達模式查閱更多表達數據基因本體分子功能• sequence-specific DNA binding• transcription corepressor activity• 鋅離子結合• 金屬離子結合• steroid hormone receptor activity• 血漿蛋白結合• 酶結合• chromatin DNA binding• thyroid hormone binding• DNA結合轉錄因子活性• DNA結合• DNA-binding transcription factor activity, RNA polymerase II-specific• transcription cis-regulatory region binding• RNA polymerase II transcription regulatory region sequence-specific DNA binding• 轉錄因子結合• nuclear receptor coactivator activity• signaling receptor activity• nuclear receptor activity細胞組分• 核質• 細胞核• nuclear body• RNA polymerase II transcription regulator complex生物學過程• regulation of transcription, DNA-templated• regulation of heart contraction• female courtship behavior• regulation of transcription by RNA polymerase II• negative regulation of transcription by RNA polymerase II• 聽覺• type I pneumocyte differentiation• negative regulation of female receptivity• animal organ morphogenesis• transcription initiation from RNA polymerase II promoter• negative regulation of transcription, DNA-templated• positive regulation of transcription by RNA polymerase II• steroid hormone mediated signaling pathway• intracellular receptor signaling pathway• transcription, DNA-templated• negative regulation of eye photoreceptor cell development• retinal cone cell development• retinal cone cell apoptotic process• multicellular organism development• hormone-mediated signaling pathway• 細胞分化• 甲狀旁腺的發生• response to lipid• thyroid hormone mediated signaling pathwaySources:Amigo / QuickGO直系同源物種人類小鼠Entrez706821834EnsemblENSG00000151090ENSMUSG00000021779UniProtP10828P37242mRNA序列NM_000461NM_001128176NM_001128177NM_001252634NM_001354708NM_001354709NM_001354710NM_001354711NM_001354712NM_001354713NM_001354714NM_001354715NM_001374822NM_001374823NM_001374824NM_001374825NM_001374826NM_001374827NM_001113417NM_009380蛋白序列NP_000452NP_001121648NP_001121649NP_001239563NP_001341637NP_001341638NP_001341639NP_001341640NP_001341641NP_001341642NP_001341643NP_001341644NP_001361751NP_001361752NP_001361753NP_001361754NP_001361755NP_001361756NP_001106888NP_033406基因位置(UCSC)Chr 3: 24.12 – 24.5 MbChr 14: 4.43 – 4.81 MbPubMed查找[5][6]維基數據檢視/編輯人類檢視/編輯小鼠Close
甲狀腺激素β受體(TR-β,或THR-β)也稱為核受體亞家族1,A 組,成員2(NR1A2),是一種核受體蛋白,在人類中由THR-β基因編碼。[7][8] Quick Facts 甲狀腺激素β受體, 已知的結構 ...甲狀腺激素β受體已知的結構PDB直系同源搜尋: PDBe RCSB PDBID列表1BSX、1N46、1NAX、1NQ0、1NQ1、1NQ2、1NUO、1Q4X、1R6G、1XZX、1Y0X、2J4A、2NLL、2PIN、3D57、3GWS、3IMY、3JZC、4ZO1識別號別名THRB;, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2, thyroid hormone receptor beta, TRbeta外部IDOMIM:190160 MGI:98743 HomoloGene:36025 GeneCards:THRB 相關疾病selective pituitary resistance to thyroid hormone、generalized resistance to thyroid hormone[1]為以下藥物的標靶反三碘甲狀腺原氨酸、替拉曲可、三碘甲腺原氨酸、左旋甲狀腺素鈉[2]基因位置(人類)染色體3號染色體[3]基因座3p24.2起始24,117,153 bp[3]終止24,495,756 bp[3]基因位置(小鼠)染色體小鼠14號染色體[4]基因座14|14 A1起始4,431,611 bp[4]終止4,809,435 bp[4]RNA表達模式查閱更多表達數據基因本體分子功能• sequence-specific DNA binding• transcription corepressor activity• 鋅離子結合• 金屬離子結合• steroid hormone receptor activity• 血漿蛋白結合• 酶結合• chromatin DNA binding• thyroid hormone binding• DNA結合轉錄因子活性• DNA結合• DNA-binding transcription factor activity, RNA polymerase II-specific• transcription cis-regulatory region binding• RNA polymerase II transcription regulatory region sequence-specific DNA binding• 轉錄因子結合• nuclear receptor coactivator activity• signaling receptor activity• nuclear receptor activity細胞組分• 核質• 細胞核• nuclear body• RNA polymerase II transcription regulator complex生物學過程• regulation of transcription, DNA-templated• regulation of heart contraction• female courtship behavior• regulation of transcription by RNA polymerase II• negative regulation of transcription by RNA polymerase II• 聽覺• type I pneumocyte differentiation• negative regulation of female receptivity• animal organ morphogenesis• transcription initiation from RNA polymerase II promoter• negative regulation of transcription, DNA-templated• positive regulation of transcription by RNA polymerase II• steroid hormone mediated signaling pathway• intracellular receptor signaling pathway• transcription, DNA-templated• negative regulation of eye photoreceptor cell development• retinal cone cell development• retinal cone cell apoptotic process• multicellular organism development• hormone-mediated signaling pathway• 細胞分化• 甲狀旁腺的發生• response to lipid• thyroid hormone mediated signaling pathwaySources:Amigo / QuickGO直系同源物種人類小鼠Entrez706821834EnsemblENSG00000151090ENSMUSG00000021779UniProtP10828P37242mRNA序列NM_000461NM_001128176NM_001128177NM_001252634NM_001354708NM_001354709NM_001354710NM_001354711NM_001354712NM_001354713NM_001354714NM_001354715NM_001374822NM_001374823NM_001374824NM_001374825NM_001374826NM_001374827NM_001113417NM_009380蛋白序列NP_000452NP_001121648NP_001121649NP_001239563NP_001341637NP_001341638NP_001341639NP_001341640NP_001341641NP_001341642NP_001341643NP_001341644NP_001361751NP_001361752NP_001361753NP_001361754NP_001361755NP_001361756NP_001106888NP_033406基因位置(UCSC)Chr 3: 24.12 – 24.5 MbChr 14: 4.43 – 4.81 MbPubMed查找[5][6]維基數據檢視/編輯人類檢視/編輯小鼠Close