載脂蛋白B

載脂蛋白B（英語：Apolipoprotein B，縮寫ApoB，也稱為脂蛋白B100 英語：Apolipoprotein B100）是乳糜微粒、極低密度脂蛋白、中密度脂蛋白（英語：intermediate-density lipoprotein）、低密度脂蛋白上的主要載脂蛋白^[6][7]，其由人類APOB基因編碼。

載脂蛋白B
識別號
別名	APOB；, FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B, FCHL2
外部ID	OMIM：107730 MGI：88052 HomoloGene：328 GeneCards：APOB
相關疾病
代謝疾病、​心血管疾病、​血脂異常、​familial hypobetalipoproteinemia 1、​hypercholesterolemia, autosomal dominant, type b、​家族性高膽固醇血症、​hypobetalipoproteinemia[1]
基因位置（人類） 染色體 2號染色體[2] 基因座 2p24.1 起始 21,001,429 bp[2] 終止 21,044,073 bp[2]
基因位置（小鼠） 染色體 小鼠12號染色體[3] 基因座 12 A1.1|12 3.53 cM 起始 8,027,648 bp[3] 終止 8,066,835 bp[3]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • 血漿蛋白結合 • lipid binding • lipid transporter activity • cholesterol transfer activity • lipase binding • low-density lipoprotein particle receptor binding • phospholipid binding • heparin binding • signaling receptor binding 細胞組分 • 早期內吞體 • chylomicron remnant • vesicle lumen • 內質網 • endosome membrane • mature chylomicron • endoplasmic reticulum lumen • vesicle membrane • endosome lumen • intermediate-density lipoprotein particle • clathrin-coated endocytic vesicle membrane • endoplasmic reticulum membrane • 外排體 • endocytic vesicle lumen • soma • 細胞質 • 乳糜微粒 • very-low-density lipoprotein particle • low-density lipoprotein particle • endoplasmic reticulum exit site • 細胞外空間 • smooth endoplasmic reticulum • 細胞質基質 • 細胞膜 • lysosomal lumen • 細胞內膜結合細胞器 • 細胞外區域 • high-density lipoprotein particle 生物學過程 • artery morphogenesis • in utero embryonic development • 受精 • 受體介導的內吞作用 • positive regulation of cholesterol storage • 脂質代謝 • cholesterol metabolic process • cholesterol transport • regulation of cholesterol biosynthetic process • lipid transport • 神經系統的發育 • leukocyte migration • response to carbohydrate • retinoid metabolic process • steroid metabolic process • triglyceride mobilization • lipid catabolic process • response to lipopolysaccharide • positive regulation of macrophage derived foam cell differentiation • cellular response to prostaglandin stimulus • response to virus • positive regulation of lipid storage • cellular response to tumor necrosis factor • response to selenium ion • flagellated sperm motility • positive regulation of gene expression • response to organic substance • cholesterol homeostasis • 精子發生 • triglyceride catabolic process • cholesterol efflux • post-embryonic development • lipoprotein transport • toll-like receptor signaling pathway • response to estradiol • membrane organization • chylomicron remodeling • low-density lipoprotein particle remodeling • chylomicron assembly • very-low-density lipoprotein particle assembly • chylomicron remnant clearance • low-density lipoprotein particle clearance • very-low-density lipoprotein particle clearance • lipoprotein metabolic process • lipoprotein biosynthetic process • lipoprotein catabolic process • 翻譯後修飾 • transport Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	338	238055
Ensembl	ENSG00000084674	ENSMUSG00000020609
UniProt	P04114	E9Q414
mRNA​序列	NM_000384	NM_009693
蛋白序列	NP_000375	NP_033823
基因位置​（UCSC）	Chr 2: 21 – 21.04 Mb	Chr 12: 8.03 – 8.07 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

參考文獻

1. 與载脂蛋白B相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000084674 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000020609 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Lim JS, Lee DH, Park JY, Jin SH, Jacobs DR. Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement. Journal of Clinical Lipidology. 2011, 5 (4): 264–272. PMID 21784371. doi:10.1016/j.jacl.2011.05.004.
7. Jacobson TA. Opening a new lipid "apo-thecary": incorporating apolipoproteins as potential risk factors and treatment targets to reduce cardiovascular risk. Mayo Clinic Proceedings. 2011, 86 (8): 762–780. PMC 3146376 . PMID 21803958. doi:10.4065/mcp.2011.0128.

外部連結

• Database of RNA editing (DARNED) （頁面存檔備份，存於網際網路檔案館）.
• Applied Research on Apolipoprotein-B （頁面存檔備份，存於網際網路檔案館）
• Human APOB genome location and APOB gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.