腺苷A2A受體

腺苷A_2A受體(adenosine A_2A receptor)，也稱為ADORA2A，是一種腺苷受體，也表示編碼它的人類基因。^[6][7]

腺苷A2A受體
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 2YDO、​2YDV、​3EML、​3PWH、​3QAK、​3REY、​3RFM、​3UZA、​3UZC、​3VG9、​3VGA、​4EIY、​4UG2、​4UHR、​5IU4、​5IU7、​5IUA、​5IU8、​5IUB
識別號
別名	ADORA2A；, adenosine A2a receptor, A2aR, ADORA2, RDC8
外部ID	OMIM：102776 MGI：99402 HomoloGene：20166 GeneCards：ADORA2A
為以下藥物的標靶
腺苷、​BAY 60-6583、​Regadenoson、​UK-432,097、​CCPA、​CGS-21680、​cyclopentyladenosine、​咖啡因、​CGS 15943、​8-環戊基-1,3-二丙基黃嘌呤、​flavone、​高良姜素、​istradefylline、​桑色素、​瑞德南特、​rolofylline、​櫻花素、​sch-442416、​sch-58261、​茶鹼、​ZM-241385[1]
基因位置（人類） 染色體 22號染色體[2] 基因座 22q11.23 起始 24,417,879 bp[2] 終止 24,442,357 bp[2]
基因位置（小鼠） 染色體 小鼠10號染色體[3] 基因座 10|10 C1 起始 75,152,711 bp[3] 終止 75,170,618 bp[3]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • G protein-coupled adenosine receptor activity • G protein-coupled receptor activity • signal transducer activity • 血漿蛋白結合 • 相同蛋白質結合 • 酶結合 • alpha-actinin binding • type 5 metabotropic glutamate receptor binding • protein heterodimerization activity 細胞組分 • integral component of membrane • 膜 • 細胞膜 • integral component of plasma membrane • 中間纖維 • 內膜系統 • 突觸後緻密物質 • 軸突 • 樹突 • axolemma • asymmetric synapse • presynaptic membrane • soma • postsynaptic membrane • presynaptic active zone • integral component of postsynaptic membrane • integral component of presynaptic membrane • glutamatergic synapse • Golgi membrane 生物學過程 • cAMP biosynthetic process • G protein-coupled adenosine receptor signaling pathway • sensory perception • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cell-cell signaling • 凝血 • blood circulation • cellular defense response • central nervous system development • 吞噬作用 • inflammatory response • 訊息傳遞 • 細胞凋亡 • synaptic transmission, dopaminergic • response to amphetamine • regulation of transcription, DNA-templated • negative regulation of protein kinase activity • protein kinase C-activating G protein-coupled receptor signaling pathway • synaptic transmission, cholinergic • locomotory behavior • negative regulation of cell population proliferation • positive regulation of glutamate secretion • positive regulation of acetylcholine secretion, neurotransmission • regulation of norepinephrine secretion • response to caffeine • positive regulation of synaptic transmission, GABAergic • synaptic transmission, glutamatergic • positive regulation of urine volume • positive regulation of renal sodium excretion • negative regulation of locomotion • 血管舒張 • eating behavior • negative regulation of vascular permeability • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to alkaloid • negative regulation of neuron apoptotic process • positive regulation of circadian sleep/wake cycle, sleep • negative regulation of alpha-beta T cell activation • astrocyte activation • neuron projection morphogenesis • positive regulation of protein secretion • negative regulation of inflammatory response • regulation of mitochondrial membrane potential • membrane depolarization • regulation of calcium ion transport • positive regulation of synaptic transmission, glutamatergic • 興奮性動作電位 • 抑制性突觸 • 前脈衝抑制 • positive regulation of apoptotic signaling pathway • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of long-term synaptic potentiation • regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	135	11540
Ensembl	ENSG00000128271	ENSMUSG00000020178
UniProt	P29274	Q60613
mRNA​序列	NM_000675 ​NM_001278497 ​NM_001278498 ​NM_001278499 ​NM_001278500	NM_009630 ​NM_001331095 ​NM_001331096
蛋白序列	NP_000666 ​NP_001265426 ​NP_001265427 ​NP_001265428 ​NP_001265429	NP_001318024 ​NP_001318025 ​NP_033760
基因位置​（UCSC）	Chr 22: 24.42 – 24.44 Mb	Chr 10: 75.15 – 75.17 Mb
PubMed​查找	[4]	[5]
維基數據
檢視/編輯人類 檢視/編輯小鼠

參考資料

1. 對Adenosine A2a receptor起作用的藥物；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000128271 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000020178 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, et al. Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science. May 1989, 244 (4904): 569–72. Bibcode:1989Sci...244..569L. PMID 2541503. doi:10.1126/science.2541503.
7. Libert F, Passage E, Parmentier M, Simons MJ, Vassart G, Mattei MG. Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. Genomics. September 1991, 11 (1): 225–7. PMID 1662665. doi:10.1016/0888-7543(91)90125-X.

深入閱讀

• Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology. August 2011, 163 (7): 1344–64. PMC 3165946 . PMID 21749363. doi:10.1111/j.1476-5381.2011.01238.x.
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• Makujina SR, Sabouni MH, Bhatia S, Douglas FL, Mustafa SJ. Vasodilatory effects of adenosine A2 receptor agonists CGS 21680 and CGS 22492 in human vasculature. European Journal of Pharmacology. October 1992, 221 (2–3): 243–7. PMID 1426003. doi:10.1016/0014-2999(92)90708-C.
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• Libert F, Passage E, Parmentier M, Simons MJ, Vassart G, Mattei MG. Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. Genomics. September 1991, 11 (1): 225–7. PMID 1662665. doi:10.1016/0888-7543(91)90125-X.
• Martinez-Mir MI, Probst A, Palacios JM. Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease. Neuroscience. 1992, 42 (3): 697–706. PMID 1835521. S2CID 23693441. doi:10.1016/0306-4522(91)90038-P.
• Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, et al. Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science. May 1989, 244 (4904): 569–72. Bibcode:1989Sci...244..569L. PMID 2541503. doi:10.1126/science.2541503.
• Kim J, Wess J, van Rhee AM, Schöneberg T, Jacobson KA. Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. The Journal of Biological Chemistry. June 1995, 270 (23): 13987–97. PMC 3427751 . PMID 7775460. doi:10.1074/jbc.270.23.13987.
• Szondy Z. Adenosine stimulates DNA fragmentation in human thymocytes by Ca(2+)-mediated mechanisms. The Biochemical Journal. 304. December 1994,. 304 ( Pt 3) (3): 877–85. PMC 1137415 . PMID 7818494. doi:10.1042/bj3040877.
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外部連結

• Human ADORA2A genome location and ADORA2A gene details page in the UCSC Genome Browser（英語：UCSC Genome Browser）.