合胞素-1

合胞素-1
識別號
別名	ERVW-1；, ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV, endogenous retrovirus group W member 1, endogenous retrovirus group W member 1, envelope
外部ID	OMIM：604659 HomoloGene：137309 GeneCards：ERVW-1
基因位置（人類）
染色體	7號染色體
終止	92,477,986 bp
直系同源
	30816
	無數據
	ENSG00000242950
	無數據
	Q9UQF0
	無數據
	NM_014590; NM_001130925
	無數據
	NP_001124397; NP_055405
	無數據
	維基數據
檢視/編輯人類

合胞素-1（Syncytin-1，enverin）是一種在人類和其他靈長類動物中發現的蛋白質，它由ERVW-1基因編碼。該基因是一種內源性病毒元件，它是2500萬年前逆轉錄病毒感染人類後的殘餘物^[3]。合胞素有助於胎盤發育^[4]^[5]^[6]。

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參考文獻

[1]
GRCh38: Ensembl release 89: ENSG00000242950 - Ensembl, May 2017
[2]
Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
[3]
Phylogeny of a novel family of human endogenous retrovirus sequences, HERV-W, in humans and other primates. AIDS Research and Human Retroviruses. November 1999, 15 (17): 1529–33. PMID 10580403. doi:10.1089/088922299309810.
[4]
From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation. Placenta. September 2012, 33 (9): 663–71. PMID 22695103. doi:10.1016/j.placenta.2012.05.005.
[5]
The role of syncytins in human reproduction and reproductive organ cancers. Reproduction (Cambridge, England). 2016, 152 (5): R167–78. PMID 27486264. doi:10.1530/REP-16-0031.
[6]
Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. September 2013, 368 (1626): 20120507. PMC 3758191 . PMID 23938756. doi:10.1098/rstb.2012.0507.