PAS結構域

PAS結構域（英語：PAS domain）也稱為PAS摺疊（英語：PAS fold）是一種在細菌、古菌和真核生物中都存在的蛋白質結構域^[2]。其功能為檢測小分子物質，如檢測氧氣的EPAS1等^[3][4][5]。

PAS摺疊
細菌的氧氣感受蛋白fixL的PAS結構域的晶體結構[1]。蛋白以飄帶圖展示，其中N-末端為藍色，C-末端為紅色，中間為血紅素
鑑定
標誌	PAS
Pfam	PF00989（舊版）
InterPro（英語：InterPro）	IPR013767
SMART（英語：Simple Modular Architecture Research Tool）	PAS
PROSITE（英語：PROSITE）	PDOC50112
SCOP（英語：Structural Classification of Proteins）	2phy / SUPFAM
CDD（英語：Conserved Domain Database）	cd00130
現有可用的蛋白結構： Pfam 結構（舊版） / ECOD PDB RCSB PDB; PDBe; PDBj PDBsum（英語：PDBsum） 結構概要 PDB 1byw, 1d06, 1d7e, 1dp6, 1dp8, 1dp9, 1drm, 1ew0, 1f98, 1f9i, 1gsv, 1gsw, 1gsx, 1kou, 1ll8, 1lsv, 1lsw, 1lsx, 1lt0, 1mzu, 1nwz, 1odv, 1ot6, 1ot9, 1ota, 1otb, 1otd, 1ote, 1oti, 1s1y, 1s1z, 1s4r, 1s4s, 1s66, 1s67, 1t18, 1t19, 1t1a, 1t1b, 1t1c, 1ts0, 1ts6, 1ts7, 1ts8, 1ugu, 1uwn, 1uwp, 1v9y, 1v9z, 1vb6, 1wa9, 1xfn, 1xfq, 1xj2, 1xj3, 1xj4, 1xj6, 1y28, 2d01, 2d02, 2phy, 2pyp, 2pyr, 3phy, 3pyp

參考文獻

1. PDB 1y28; Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA. A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure. Biochemistry. July 2003, 42 (25): 7701–8 [2023-01-04]. PMID 12820879. doi:10.1021/bi0343370. （原始內容存檔於2023-01-20）.
2. Henry, Jonathan T.; Crosson, Sean. Ligand-binding PAS domains in a genomic, cellular, and structural context. Annual Review of Microbiology. 1 January 2011, 65: 261–286. PMC 3298442 . PMID 21663441. doi:10.1146/annurev-micro-121809-151631.
3. Liu, Yu C.; Machuca, Mayra A.; Beckham, Simone A.; Gunzburg, Menachem J.; Roujeinikova, Anna. Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains. Acta Crystallographica Section D. 1 October 2015, 71 (10): 2127–2136. PMID 26457436. doi:10.1107/S139900471501384X.
4. Möglich, Andreas; Ayers, Rebecca A.; Moffat, Keith. Structure and signaling mechanism of Per-ARNT-Sim domains. Structure. 14 October 2009, 17 (10): 1282–1294. PMC 3092527 . PMID 19836329. doi:10.1016/j.str.2009.08.011.
5. Hennig, Sven; Strauss, Holger M.; Vanselow, Katja; Yildiz, Özkan; Schulze, Sabrina; Arens, Julia; Kramer, Achim; Wolf, Eva. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLOS Biology. 28 April 2009, 7 (4): e1000094. PMC 2671562 . PMID 19402751. doi:10.1371/journal.pbio.1000094.