層粘連蛋白亞基α1是一個層粘連蛋白的蛋白亞基。層粘蛋白是一種組成核纖層的蛋白，在細胞核的形態維持中扮演重要角色。此蛋白質在人體內由LAMA1基因編碼[7][8]。 事实速览 LAMA1, 已知的結構 ...LAMA1已知的結構PDB直系同源搜索: PDBe RCSB PDBID列表2JD4識別號別名LAMA1；, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1外部IDOMIM：150320 MGI：99892 HomoloGene：21146 GeneCards：LAMA1 相關疾病2型糖尿病、ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome[1]為以下藥物的標靶ocriplasmin[2]基因位置（人類）染色體18號染色體[3]基因座18p11.31起始6,941,742 bp[3]終止7,117,797 bp[3]基因位置（小鼠）染色體小鼠17號染色體[4]基因座17 E1.1|17 38.8 cM起始68,004,254 bp[4]終止68,129,642 bp[4]RNA表達模式查閱更多表達數據基因本體分子功能• signaling receptor binding• extracellular matrix structural constituent• 血漿蛋白結合• protein C-terminus binding• glycosphingolipid binding細胞組分• 細胞外間質• 細胞外區域• 基底膜• laminin-1 complex• laminin-3 complex• 細胞外空間• 膜• cell-cell junction• laminin complex• collagen-containing extracellular matrix生物學過程• cell surface receptor signaling pathway• regulation of cell adhesion• 細胞粘附• extracellular matrix organization• regulation of cell migration• regulation of embryonic development• morphogenesis of an epithelial sheet• protein phosphorylation• 組織發生• neuron projection development• establishment of epithelial cell apical/basal polarity• retina development in camera-type eye• epithelial tube branching involved in lung morphogenesis• branching involved in salivary gland morphogenesis• retinal blood vessel morphogenesis• 軸突導向• animal organ morphogenesis• camera-type eye development• blood vessel morphogenesisSources:Amigo / QuickGO直系同源物種人類小鼠Entrez28421716772EnsemblENSG00000101680ENSMUSG00000032796UniProtP25391P19137mRNA序列NM_005559NM_008480蛋白序列NP_005550NP_032506基因位置（UCSC）Chr 18: 6.94 – 7.12 MbChr 17: 68 – 68.13 MbPubMed查找[5][6]維基數據檢視/編輯人類檢視/編輯小鼠关闭 相互作用 層粘蛋白亞基α1會與FBLN2（英語：FBLN2）發生蛋白質相互作用[9][10]。 參考資料 [1]與LAMA1相關的疾病；在維基數據上查看/編輯參考. [2]對Laminin subunit alpha 1起作用的藥物；在維基數據上查看/編輯參考. [3]GRCh38: Ensembl release 89: ENSG00000101680 - Ensembl, May 2017 [4]GRCm38: Ensembl release 89: ENSMUSG00000032796 - Ensembl, May 2017 [5]Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. [6]Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. [7]Nagayoshi, T.; Mattei, M. G.; Passage, E.; Knowlton, R.; Chu, M. L.; Uitto, J. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. Genomics. 1989-11, 5 (4): 932–935 [2021-11-10]. ISSN 0888-7543. PMID 2591971. doi:10.1016/0888-7543(89)90136-5. （原始內容存檔於2021-11-10）. [8]LAMA1 laminin subunit alpha 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始內容存檔於2021-11-10）. [9]Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. 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