趨化因子受體CXCR3是G蛋白偶連的七跨膜域受體，可選擇性地與CXC趨化因子（CXCL9，CXCL10，和CXCL11）結合[1]。 CXCR3又稱G蛋白偶聯受體9(GPR9)和CD183。有兩種變異的CXCR3受體。CXCR3－A與CXCL9， CXCL10，CXCL11結合；而CXCR3-B除了與CXCL9， CXCL10，CXCL11結合外還可以與CXCL4結合[2]。
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CXCR3主要表達在T細胞、自然殺傷細胞活性上[3]，有的上皮細胞和一些內皮細胞也表達CXCR3。 I型輔助T細胞（Th1）優先表達CXCR3及CCR5[3]，而II型輔助T細胞（Th2）表達CCR3和CCR4。 CXCR3與配體結合後在誘導I型輔助T細胞（Th1）遷移的同時又阻止II型輔助T細胞（Th2）的遷徙。從而增強T細胞的分化效應。
CXCR3與其配體CXCL9， CXCL10，CXCL11的結合，能引起細胞鈣離子的內流，啟動肌醇磷脂3-激酶和絲裂原活化蛋白激酶（MAPK）[4]。詳細的信號通路尚未確立，但與其他的趨化因子受體的信號傳遞有類似的激酶。
CXCR3調節白細胞遷徙。CXCR3與配體相互作用引起I型輔助T細胞（Th1）的遷移，並促進I型輔助T細胞（Th1）成熟。
CXCR3可能在下列疾病中起作用，包括動脈粥樣硬化[5]、多發性硬化[6]、肺纖維化[7], I型糖尿病[8]，重症肌無力、急性心臟移植排斥[9]。開發阻斷CXCR3與其配體相互作用的藥物可提供治療這些疾病的新途徑。
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