CXCL11

CXCL11（英語：Chemokine (C-X-C motif) ligand 11）是一小分子的細胞因子屬於CXC趨化因子家族^[1]，又被稱作「干擾素誘導的T細胞a趨化因子」（Interferon-inducible T-cell alpha chemoattractant (I-TAC)^[1]。

Chemokine (C-X-C motif) ligand 11
PDB rendering based on 1rjt.
有效結構 PDB 直系同源檢索：PDBe, RCSB PDB查詢代碼列表 1RJT
標識
代號	CXCL11; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B; b-R1
擴展標識	遺傳學：604852 鼠基因：1860203 同源基因：3944 GeneCards: CXCL11 Gene
基因本體論描述 分子功能 · chemokine activity 細胞成分 · extracellular region · extracellular space 生物過程 · chemotaxis · inflammatory response · immune response · signal transduction · cell-cell signaling Sources: Amigo / QuickGO
RNA表達模式
更多表達數據
直系同源體
物種	人類	小鼠
Entrez	6373	56066
Ensembl	ENSG00000169248	n/a
UniProt	O14625	Q9JHH5
mRNA序列	NM_005409	NM_019494.1
蛋白序列	NP_005400	NP_062367.1
基因位置	Chr 4: 76.95 – 76.96 Mb	n/a
PubMed查詢	[1]	[2]
閱 論 編

表達

在白細胞，胰腺和肝臟中表達水平高，在胸腺，脾和肺有中等水平的表達，在小腸，胎盤和前列腺中表達水平低^[1]。干擾素伽瑪和干擾素－b可以在單核細胞^[1]，支氣管上皮細胞^[2]，中性粒細胞^[3]，角質形成細胞^[4]，和內皮細胞誘導CXCL11的表達。

受體

CXCL11結合趨化因子受體CXCR3而起其細胞趨化作用^[1][5][6]。CXCL11也可以結合到趨化因子受體CCR3上而阻止CCR3配體的結合^[7]。

功能

CXCL11對活化的T細胞，中性粒細胞和單核細胞有細胞趨化作用^[1]。

參見

• 趨化因子
• CXCR3
• CXCL9
• CXCL10

參考文獻

1. Cole et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 187: 2009-2021, 1998.
2. Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999) The T cell-specific CXC chemokines IP-10, MIG, and I-TAC are expressed by activated human bronchial epithelial cells J. Immunol. 162,3549-3558
3. Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M., Liao, F., Farber, J., Cassatella, M. A. (1999) Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils J. Immunol. 162,4928-4937.
4. Tensen, C. P., Flier, J., Van Der Raaij-Helmer, E. M., Sampat-Sardjoepersad, S., Van Der Schors, R. C., Leurs, R., Scheper, R. J., Boorsma, D. M., Willemze, R. (1999) Human IP-9: a keratinocyte-derived high-affinity CXC-chemokine ligand for the IP-10/MIG receptor (CXCR3) J. Invest. Dermatol. 112,716-72.
5. Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
6. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
7. Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 Feb 2;276(5):2986-91

外部連結

• Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（頁面存檔備份，存於網際網路檔案館）