CD132

CD132，又稱為共用γ鏈（Common gamma chain，縮寫γ_c)，白介素2受體γ亞基（interleukin-2 receptor subunit gamma，縮寫IL-2RG）是一種細胞因子受體亞基，存在於至少六種不同的白介素受體中：包括IL-2、IL-4^[7]、IL-7^[8]、IL-9、IL-15^[9]和IL-21的受體。γ_c是I型細胞因子受體家族中的一種醣蛋白，表達於大部分的淋巴細胞群體，哺乳動物的此基因位於X染色體。

CD132
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 2B5I、​2ERJ、​3BPL、​3QAZ、​3QB7、​4GS7
識別號
別名	IL2RG；, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
外部ID	OMIM：308380 MGI：96551 HomoloGene：172 GeneCards：IL2RG
相關疾病
X性聯嚴重複合免疫缺乏症、​combined immunodeficiency, X-linked[1]
為以下藥物的標靶
denileukin diftitox[2]
基因位置（人類） 染色體 X染色體[3] 基因座 Xq13.1 起始 71,107,404 bp[3] 終止 71,112,108 bp[3]
基因位置（小鼠） 染色體 小鼠X染色體[4] 基因座 X D|X 43.9 cM 起始 100,307,984 bp[4] 終止 100,311,861 bp[4]
RNA表達模式
查閱更多表達數據
基因本體 分子功能 • interleukin-7 receptor activity • interleukin-2 receptor activity • 血漿蛋白結合 • cytokine receptor activity • interleukin-4 receptor activity • interleukin-2 binding • cytokine binding • interleukin-15 receptor activity 細胞組分 • integral component of membrane • 膜 • 細胞膜 • integral component of plasma membrane • external side of plasma membrane • 核內體 • 細胞質基質 • cell surface • receptor complex 生物學過程 • MAPK cascade • 免疫反應 • viral process • 訊息傳遞 • interleukin-2-mediated signaling pathway • interleukin-4-mediated signaling pathway • interleukin-7-mediated signaling pathway • interleukin-15-mediated signaling pathway • interleukin-9-mediated signaling pathway • 分子功能調控 • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • positive regulation of phagocytosis Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	3561	16186
Ensembl	ENSG00000147168	ENSMUSG00000031304
UniProt	P31785	P34902
mRNA​序列	NM_000206	NM_013563 ​NM_001308535
蛋白序列	NP_000197	NP_001295464 ​NP_038591
基因位置​（UCSC）	Chr X: 71.11 – 71.11 Mb	Chr X: 100.31 – 100.31 Mb
PubMed​查找	[5]	[6]
維基數據
檢視/編輯人類 檢視/編輯小鼠

參考文獻

1. 與CD132相關的疾病；在維基數據上查看/編輯參考.
2. 對Interleukin 2 receptor subunit gamma起作用的藥物；在維基數據上查看/編輯參考.
3. GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017
4. GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. December 1993, 262 (5141): 1880–3. PMID 8266078. doi:10.1126/science.8266078.
8. Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science. December 1993, 262 (5141): 1877–80. PMID 8266077. doi:10.1126/science.8266077.
9. Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. August 1995, 14 (15): 3654–63. PMC 394440 . PMID 7641685.

延伸閱讀

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外部連結

• 醫學主題詞表（MeSH）：Interleukin+Receptor+Common+gamma+Subunit