依替福林

依替福林
臨床資料
其他名稱	(2-乙氨基-1-(3'-羥基苯基)乙醇
AHFS/Drugs.com	國際藥品名稱
ATC碼	C01CA01 (WHO) ;
識別資訊
	IUPAC命名法 (RS)-3-[2-(ethylamino)-1-hydroxyethyl]phenol; ;
CAS號	709-55-7
PubChem CID	3306;
DrugBank	DB08985 ;
ChemSpider	3190 ;
UNII	ZB6F8MY53V;
KEGG	D07931 ;
ChEMBL	ChEMBL86882 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID1023029 ;
ECHA InfoCard	100.010.829
化學資訊
化學式	C10H15NO2
摩爾質量	181.24 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
手性	外消旋混合物
	SMILES CCNCC(O)c1cc(O)ccc1;
	InChI InChI=1S/C10H15NO2/c1-2-11-7-10(13)8-4-3-5-9(12)6-8/h3-6,10-13H,2,7H2,1H3 ; Key:SQVIAVUSQAWMKL-UHFFFAOYSA-N ;

依替福林（INN：etilefrine）是一種強心劑，用作抗低血壓藥物。它是3-羥基苯乙醇胺系列的擬交感胺，用於治療神經、心血管、內分泌或代謝引起的直立性低血壓。靜脈輸注該化合物可增加人和實驗動物的心輸出量、每搏輸出量、靜脈回流和血壓，這表明其可刺激α和β腎上腺素受體。^[1]^[2]^[3]^[4]^[5]然而，體外研究表明依替福林對β₁（心臟）的親和力比對β₂腎上腺素受體的親和力高得多。^[6]

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參考資料

[1]
Nusser E, Donath H, Russ W. [On the circulatory action of depot-Effortil in patients with hypotonic regulation circulator disorders]. Die Medizinische Welt. August 1965, 32: 1824–7. PMID 5320529 （German）.
[2]
Mellander S. Comparative effects of acetylcholine, butyl-nor-synephrine (Vasculat), noradrenaline, and ethyl-adrainol (Effonti) on resistance, capacitance, and precapillary sphincter vessels and capillary filtration in cat skeletal muscle. Angiologica. 1966, 3 (2): 77–99. PMID 4380206. doi:10.1159/000157650.
[3]
von Limbourg P, Just H, Lang KF. Positive inotrope Wirkung von Etilefrinhydrochlorid (EffortilR). Kardiol. 1973, 586: 1.
[4]
Tarnow J, Brückner JB, Eberlein HG, Patschke D, Reinecke A, Schmicke P. Experimentelle Untersuchungen zur Beeinflussung der Hämodynamik in tiefer Halothannarkose durch Dopamin, Glucagon, Effortil, Noradrenalin und Dextran. Der Anaesthesist. 1973, 22: 8–15.
[5]
Carrera AL, Aguilera AM. Algunos effectos circulatorios de la m− oxifenil etanol etilmaina y sus modificaciones por el bloqueo α y β adrenergico.. Arch. Inst. Cardiol. (Mexico). 1973, 43: 279–287.
[6]
Offermeier J, Dreyer AC. A comparison of the effects of noradrenaline, adrenaline and some phenylephrine derivatives on alpha-, beta- and beta- adrenergic receptors. South African Medical Journal = Suid-Afrikaanse Tydskrif vir Geneeskunde. March 1971, 45 (10): 265–7. PMID 4396765.

外部連結

Etilefrine. PubChem. [2024-03-25]. （原始內容存檔於2013-10-04）.
Etilefrine. Kegg. [2024-03-25]. （原始內容存檔於2024-03-25）.

[Nusser_1965-1] [1]
Nusser E, Donath H, Russ W. [On the circulatory action of depot-Effortil in patients with hypotonic regulation circulator disorders]. Die Medizinische Welt. August 1965, 32: 1824–7. PMID 5320529 （German）.

[Mellander_1966-2] [2]
Mellander S. Comparative effects of acetylcholine, butyl-nor-synephrine (Vasculat), noradrenaline, and ethyl-adrainol (Effonti) on resistance, capacitance, and precapillary sphincter vessels and capillary filtration in cat skeletal muscle. Angiologica. 1966, 3 (2): 77–99. PMID 4380206. doi:10.1159/000157650.

[3] [3]
von Limbourg P, Just H, Lang KF. Positive inotrope Wirkung von Etilefrinhydrochlorid (EffortilR). Kardiol. 1973, 586: 1.

[4] [4]
Tarnow J, Brückner JB, Eberlein HG, Patschke D, Reinecke A, Schmicke P. Experimentelle Untersuchungen zur Beeinflussung der Hämodynamik in tiefer Halothannarkose durch Dopamin, Glucagon, Effortil, Noradrenalin und Dextran. Der Anaesthesist. 1973, 22: 8–15.

[5] [5]
Carrera AL, Aguilera AM. Algunos effectos circulatorios de la m− oxifenil etanol etilmaina y sus modificaciones por el bloqueo α y β adrenergico.. Arch. Inst. Cardiol. (Mexico). 1973, 43: 279–287.

[Offermeier_1971-6] [6]
Offermeier J, Dreyer AC. A comparison of the effects of noradrenaline, adrenaline and some phenylephrine derivatives on alpha-, beta- and beta- adrenergic receptors. South African Medical Journal = Suid-Afrikaanse Tydskrif vir Geneeskunde. March 1971, 45 (10): 265–7. PMID 4396765.

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