氯甲基二丁基氯化锡

氯甲基二丁基氯化锡（DBCT）是一种有机锡化合物，化学式为C₉H₁₀Cl₂Sn，它是一种强烈且不可逆的ATP合成酶抑制剂。^[3][4][5]它可以二丁基二氯化锡和重氮甲烷在无水乙醚中反应得到。^[1]

Dibutylchloromethyltin chloride
IUPAC名 Dibutyl(chloro)(chloromethyl)stannane
别名	DBCT 二丁基氯甲基氯化锡
识别
CAS号	61553-17-1  Y
PubChem	189186
ChemSpider	164378
SMILES	CCCC[Sn](CCCC)(CCl)Cl
性质
化学式	C9H20Cl2Sn
摩尔质量	317.87 g·mol−1
外观	挥发性液体
沸点	106-110 °C（0.3 mmHg）[1]
溶解性（水）	2.7×10−4 g/100 mL（25 °C）[2]
蒸气压	0.0162 mmHg（25 °C）[2]
危险性
主要危害	有毒、发疱
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

参考文献

1. Dietmar Seyferth, Eugene G. Rochow. The Reaction of Organotin Halides with Diazomethane. Journal of the American Chemical Society. 1955-03, 77 (5): 1302–1304 [2021-12-11]. ISSN 0002-7863. doi:10.1021/ja01610a072 （英语）.
2. Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2021 ACD/Labs). Retrieved from SciFinder. [2021-12-11].
3. Cain, K; Partis, MD; Griffiths, DE. Dibutylchloromethyltin chloride, a covalent inhibitor of the adenosine triphosphate synthase complex.. The Biochemical Journal. 15 September 1977, 166 (3): 593–602. PMC 1165045 . PMID 145860. doi:10.1042/bj1660593.
4. Moore, Anthony L.; Linnett, Paul E.; Beechey, R. Brian. Dibutylchloromethyltin chloride, a potent inhibitor of electron transport in plant mitochondria. Journal of Bioenergetics and Biomembranes. August 1980, 12 (3–4): 309–323. PMID 7217044. S2CID 29130410. doi:10.1007/bf00744691.
5. Diwan, Joyce Johnson. Some effects of dibutylchloromethyltin chloride and other reagents on mitochondrial K+ flux. Journal of Bioenergetics and Biomembranes. February 1982, 14 (1): 15–22. PMID 7142136. S2CID 24153839. doi:10.1007/bf00744076.