氯乙腈是一种有机化合物,化学式为ClCH2CN,它是无色液体,是乙腈的一个氢原子被氯取代的产物。实际上,它是通过氯乙酰胺脱水制得的。[2]它是烷基化试剂,应当小心使用。[3]
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氯乙腈也可由乙腈和二氯化二硫反应得到。它进一步氯化可以得到二氯乙腈,并可和二氯化二硫发生环加成反应,得到4,5-二氯-1,2,3-二噻唑𬭩氯化物:[4]
- Cl2CHCN + S2Cl2 → [S2NC2Cl2]Cl + HCl
它和苯胺在碳酸钾、碘化钠的存在下于乙腈中反应,可以得到N-氰甲基苯胺。[5]它和三苯基膦在甲苯中回流,可以得到三苯基氰甲基氯化𬭸。[6]
"PhysProp" data were obtained from Syracuse Research Corporation of Syracuse, New York (US). Retrieved from SciFinder. [2020-11-27].
Lebeuf, Raphaël; Berlande, Muriel; Robert, Frédéric; Landais, Yannick. Preparation of (3,5-Dimethoxy-1-Phenyl-Cyclohexa-2,5-Dienyl)-Acetonitrile Through Birch Reductive Alkylation (BRA). Organic Syntheses. 2009, 86: 1. doi:10.15227/orgsyn.086.0001.
Rees, Charles W. Polysulfur-Nitrogen Heterocyclic Chemistry. Journal of Heterocyclic Chemistry. 1992, 29 (3): 639–651. doi:10.1002/jhet.5570290306.
Jayaram Reddy Komsani, Sreenivas Avula, Satish Koppireddi, Pranay Kumar Koochana, Murty Usn, Rambabu Yadla. Synthesis and Antimicrobial Activity of N -Aryl-4-(cyano/alkoxycarbonyl)-5-(pyridin-3-yl)-1 H /3 H -1,2,3-triazole Derivatives: Synthesis of N-Aryl-5-(pyridin-3-yl)-4-(cyano/alkoxycarbonyl)-1,2,3-triazoles. Journal of Heterocyclic Chemistry. 2015-05, 52 (3): 764–772 [2020-11-27]. doi:10.1002/jhet.2186 (英语).