二苯基氧化膦是一种有机磷化合物,化学式为(C6H5)2P(O)H。它是白色固体,可溶于极性有机溶剂。
合成
将亚磷酸二乙酯等亚磷酸酯与格氏试剂反应,然后用酸处理反应物,可以获得二苯基氧化膦:[1]
- (C2H5O)2P(O)H + 3 C6H5MgBr → (C6H5)2P(O)MgBr + C2H5OMgBr
- (C6H5)2P(O)MgBr + HCl → (C6H5)2P(O)H + MgBrCl
反应
二苯基氧化膦与其次要互变异构体二苯基次亚膦酸((C6H5)2POH)平衡存在:
- (C
6H
5)
2P(O)H ⇌ (C
6H
5)
2POH
二苯基氧化膦在Buchwald-Hartwig偶联反应中用来引入二苯基膦取代基。[2]
氯化亚砜将二苯基氧化膦转化为二苯基氯化膦。
参考文献
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