诃黎勒酸

诃黎勒酸
识别
CAS号	23094-71-5
PubChem	442674
SMILES	C1C2C3C(C(C(O2)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C6=C5C(C(C(=O)O3)CC(=O)O)C(C(=O)O6)O)O)O)OC(=O)C7=CC(=C(C(=C7C8=C(C(=C(C=C8C(=O)O1)O)O)O)O)O)O;
InChI	1S/C41H30O27/c42-13-1-8(2-14(43)24(13)49)35(56)68-41-34-33-31(64-39(60)12(6-19(47)48)22-23-11(38(59)67-34)5-17(46)27(52)32(23)65-40(61)30(22)55)18(63-41)7-62-36(57)9-3-15(44)25(50)28(53)20(9)21-10(37(58)66-33) 4-16(45)26(51)29(21)54/h1-5,12,18,22,30-31,33-34,41-46,49-55H,6-7H2,(H,47,48)/t12-,18+,22-,30-,31+,33-,34+,41-/m0/s1;
InChIKey	HGJXAVROWQLCTP-YABCKIEDSA-N
性质
化学式	C41H30O27
摩尔质量	954.66 g/mol g·mol⁻¹
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

诃黎勒酸是一种苯并吡喃鞣质和抗氧化剂，在医学上有许多潜在用途。

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来源

诃黎勒酸存在于榄仁属的诃子、黄诃子、榄仁树等植物中，^[1]可以由老鹳草素（英语：geraniin）通过谷胱甘肽的介导形成。^[2]

应用

诃黎勒酸可以应用于免疫抑制、^[3]护肝等方面^[4]，以及作为一种强效α-葡萄糖苷酶（英语：alpha-glucosidase）抑制剂^[5]^[6]。

诃黎勒酸对金黄色葡萄球菌和白色念珠菌有很强的杀灭作用。^[7]

参考资料

[1]
Chemopreventive effect of punicalagin, a novel tannin component isolated from Terminalia catappa, on H-ras-transformed NIH3T3 cells. Pin-Shern Chen and Jih-Heng Li, Toxicology Letters（英语：Toxicology Letters）, Volume 163, Issue 1, 5 May 2006, Pages 44-53
[2]
Glutathione-mediated conversion of the ellagitannin geraniin into chebulagic acid. Tanaka T, Kouno I and Nonaka G.I, Chemical and pharmaceutical bulletin, 1996, volume 44, no 1, pages 34-40, INIST（法语：Institut de l'information scientifique et technique）:3003361
[3]
HAMADA, Shin-ichi; KATAOKA, Takao; WOO, Je-Tae; YAMADA, Atsushi; YOSHIDA, Takashi; NISHIMURA, Toshio; OTAKE, Noboru; NAGAI, Kazuo. Immunosuppressive Effects of Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity.. Biological & Pharmaceutical Bulletin. 1997, 20 (9): 1017–1019. PMID 9331989. doi:10.1248/bpb.20.1017.
[4]
Kinoshita, S.; Inoue, Y.; Nakama, S.; Ichiba, T.; Aniya, Y. Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin. Phytomedicine. November 2007, 14 (11): 755–762. PMID 17293097. doi:10.1016/j.phymed.2006.12.012.
[5]
Sasidharan, I; Sundaresan, A; Nisha, VM; Kirishna, MS; Raghu, KG; Jayamurthy, P. Inhibitory effect of Terminalia chebula Retz. fruit extracts on digestive enzyme related to diabetes and oxidative stress. J Enzyme Inhib Med Chem. 2012, 27 (4): 578–86. PMID 22512724. doi:10.3109/14756366.2011.603130.
[6]
Pham, AT; Malterud, KE; Paulsen, BS; Diallo, D; Wangensteen, H. α-Glucosidase inhibition, 15-lipoxygenase inhibition, and brine shrimp toxicity of extracts and isolated compounds from Terminalia macroptera leaves. Pharm Biol. 2014, 52 (9): 1166–9. PMID 24635511. doi:10.3109/13880209.2014.880486.
[7]
Archived copy. [2008-10-25]. （原始内容存档于2008-12-06）.

[1] [1]
Chemopreventive effect of punicalagin, a novel tannin component isolated from Terminalia catappa, on H-ras-transformed NIH3T3 cells. Pin-Shern Chen and Jih-Heng Li, Toxicology Letters（英语：Toxicology Letters）, Volume 163, Issue 1, 5 May 2006, Pages 44-53

[2] [2]
Glutathione-mediated conversion of the ellagitannin geraniin into chebulagic acid. Tanaka T, Kouno I and Nonaka G.I, Chemical and pharmaceutical bulletin, 1996, volume 44, no 1, pages 34-40, INIST（法语：Institut de l'information scientifique et technique）:3003361

[3] [3]
HAMADA, Shin-ichi; KATAOKA, Takao; WOO, Je-Tae; YAMADA, Atsushi; YOSHIDA, Takashi; NISHIMURA, Toshio; OTAKE, Noboru; NAGAI, Kazuo. Immunosuppressive Effects of Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity.. Biological & Pharmaceutical Bulletin. 1997, 20 (9): 1017–1019. PMID 9331989. doi:10.1248/bpb.20.1017.

[4] [4]
Kinoshita, S.; Inoue, Y.; Nakama, S.; Ichiba, T.; Aniya, Y. Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin. Phytomedicine. November 2007, 14 (11): 755–762. PMID 17293097. doi:10.1016/j.phymed.2006.12.012.

[5] [5]
Sasidharan, I; Sundaresan, A; Nisha, VM; Kirishna, MS; Raghu, KG; Jayamurthy, P. Inhibitory effect of Terminalia chebula Retz. fruit extracts on digestive enzyme related to diabetes and oxidative stress. J Enzyme Inhib Med Chem. 2012, 27 (4): 578–86. PMID 22512724. doi:10.3109/14756366.2011.603130.

[6] [6]
Pham, AT; Malterud, KE; Paulsen, BS; Diallo, D; Wangensteen, H. α-Glucosidase inhibition, 15-lipoxygenase inhibition, and brine shrimp toxicity of extracts and isolated compounds from Terminalia macroptera leaves. Pharm Biol. 2014, 52 (9): 1166–9. PMID 24635511. doi:10.3109/13880209.2014.880486.

[7] [7]
Archived copy. [2008-10-25]. （原始内容存档于2008-12-06）.

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