恩前列素

恩前列素是一种合成的类地诺前列酮前列腺素，它可以用来作胃部HCl分泌的强效抑制剂。^[1] 因而常被用来作抗酸或溃疡药。它的药理作用基本与米索前列醇相同。

恩前列素

临床资料
AHFS/Drugs.com	国际药品名称
ATC码	A02BB02 (WHO)
识别信息
IUPAC命名法 methyl 7-[(1S,2S,3S)-3-hydroxy-2-[(3R)-3-hydroxy-4-phenoxybut-1-enyl]-5-oxocyclopentyl]hepta-4,5-dienoate
CAS号	73121-56-9  Y
PubChem CID	51744
UNII	J4IP5Z9DAU
KEGG	D01891 Y
化学信息
化学式	C23H28O6
摩尔质量	400.46 g/mol

参考文献

1. Roszkowski, AP; Garay, GL; Baker, S; Schuler, M; Carter, H. Gastric antisecretory and antiulcer properties of enprostil, (+/−)-11 alpha, 15 alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-9-oxoprosta-4,5,13(t)-trienoic acid methyl ester. The Journal of Pharmacology and Experimental Therapeutics. 1986, 239 (2): 382–9. PMID 3095537.

外部链接

• Toshina, K.; Hirata, I.; Maemura, K.; Sasaki, S.; Murano, M.; Nitta, M.; Yamauchi, H.; Nishikawa, T.; Hamamoto, N.; Katsu, K. Enprostil, a Prostaglandin-E2 Analogue, Inhibits Interleukin-8 Production of Human Colonic Epithelial Cell Lines. Scandinavian Journal of Immunology. 2000, 52 (6): 570–5. PMID 11119262. doi:10.1046/j.1365-3083.2000.00815.x.
• Tari, Akira; Hamada, Masanori; Kamiyasu, Toshiki; Sumii, Koji; Haruma, Ken; Inoue, Masaki; Kishimoto, Shinya; Kajiyama, Goro; Walsh, John H. Effect of enprostil on omeprazole-induced hypergastrinemia and inhibition of gastric acid secretion in peptic ulcer patients. Digestive Diseases and Sciences. 1997, 42 (8): 1741–6. PMID 9286243. doi:10.1023/A:0000000000000.
• Ching, C. K.; Lam, S. K. A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease. Journal of Gastroenterology. 1995, 30 (5): 607–14. PMID 8574332. doi:10.1007/BF02367786.