ID3 (基因)

ID3（分化抑制因子3，Inhibitor of Differentiation 3），正式名称为“inhibitor of DNA binding 3, HLH protein”（DNA结合抑制因子3，HLH（螺旋-环-螺旋）蛋白）。人ID3蛋白由ID3基因编码^[5][6]。

ID3
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 2LFH
识别号
别名	ID3；, HEIR-1, bHLHb25, inhibitor of DNA binding 3, HLH protein
外部ID	OMIM：600277 MGI：96398 HomoloGene：1633 GeneCards：ID3
基因位置（人类） 染色体 1号染色体[1] 基因座 1p36.12 起始 23,557,926 bp[1] 终止 23,559,501 bp[1]
基因位置（小鼠） 染色体 小鼠4号染色体[2] 基因座 4 D3|4 68.34 cM 起始 135,870,808 bp[2] 终止 135,873,066 bp[2]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • protein dimerization activity • leptomycin B binding • transcription corepressor activity • protein domain specific binding • DNA结合转录因子活性 • 转录因子结合 • 血浆蛋白结合 • DNA-binding transcription factor activity, RNA polymerase II-specific 细胞组分 • 细胞质 • 细胞核 生物学过程 • negative regulation of myoblast differentiation • regulation of transcription, DNA-templated • epithelial cell differentiation • rhythmic process • regulation of DNA replication • muscle organ development • notochord development • negative regulation of transcription by RNA polymerase II • negative regulation of DNA-binding transcription factor activity • negative regulation of osteoblast differentiation • transcription, DNA-templated • negative regulation of gene expression • regulation of cell cycle • odontogenesis • multicellular organism development • 心脏发育 • central nervous system development • response to wounding • 昼夜节律 • neuron differentiation • positive regulation of apoptotic process • metanephros development • negative regulation of transcription, DNA-templated • cellular response to leptomycin B • negative regulation of DNA binding • negative regulation of neuron differentiation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3399	15903
Ensembl	ENSG00000283060 ​ENSG00000117318	ENSMUSG00000007872
UniProt	Q02535	P41133
mRNA​序列	NM_002167	NM_008321
蛋白序列	NP_002158	NP_032347
基因位置​（UCSC）	Chr 1: 23.56 – 23.56 Mb	Chr 4: 135.87 – 135.87 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

功能

分化抑制因子（ID）家族螺旋-环-螺旋（HLH）蛋白质缺乏基因的DNA结合结构域。它通过与其他的HLH蛋白形成异二聚体，阻止其与DNA结合，进而抑制其功能^[6]。

相互作用

ID3能与TCF3（英语：TCF3）（转录因子3）发生相互作用^[7][8]。

ID3的抑制剂

BTG2（英语：BTG2）能与ID3基因的启动子结合，进而抑制其ID3基因的活性。如果敲除海马的BTG2基因的话，海马ID3表达就会上调，进而使其神经元无法发生末端分化^[9]。

参见

• DNA结合抑制蛋白（英语：Inhibitor of DNA-binding protein）

参考

1. GRCh38: Ensembl release 89: ENSG00000283060、​ENSG00000117318 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007872 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ellmeier W, Aguzzi A, Kleiner E, Kurzbauer R, Weith A. Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. EMBO J. Aug 1992, 11 (7): 2563–71. PMC 556731 . PMID 1628620.
6. Entrez Gene: ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein. （原始内容存档于2019-10-17）.
7. Deed RW, Jasiok M, Norton JD. Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells. J. Biol. Chem. Apr 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.
8. Langlands K, Yin X, Anand G, Prochownik EV. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. Aug 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.
9. Farioli-Vecchioli S, Saraulli D, Costanzi M, Leonardi L, Cinà I, Micheli L, Nutini M, Longone P, Oh SP, Cestari V, Tirone F. Okazawa H , 编. Impaired terminal differentiation of hippocampal granule neurons and defective contextual memory in PC3/Tis21 knockout mice. PLoS ONE. 2009, 4 (12): e8339. PMC 2791842 . PMID 20020054. doi:10.1371/journal.pone.0008339.

拓展阅读

• White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C, Valentine MB, Look AT, Enomoto H, Sakiyama S, Brodeur GM. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (12): 5520–4. PMC 41727 . PMID 7777541. doi:10.1073/pnas.92.12.5520.
• Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T. Construction of a human full-length cDNA bank. Gene. 1994, 150 (2): 243–50. PMID 7821789. doi:10.1016/0378-1119(94)90433-2.
• Deed RW, Hirose T, Mitchell EL, Santibanez-Koref MF, Norton JD. Structural organisation and chromosomal mapping of the human Id-3 gene. Gene. 1994, 151 (1-2): 309–14. PMID 7828896. doi:10.1016/0378-1119(94)90676-9.
• Deed RW, Bianchi SM, Atherton GT, Johnston D, Santibanez-Koref M, Murphy JJ, Norton JD. An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types. Oncogene. 1993, 8 (3): 599–607. PMID 8437843.
• Ishiguro A, Spirin K, Shiohara M, Tobler A, Norton JD, Rigolet M, Shimbo T, Koeffler HP. Expression of Id2 and Id3 mRNA in human lymphocytes. Leuk. Res. 1995, 19 (12): 989–96. PMID 8632670. doi:10.1016/0145-2126(95)00084-4.
• Wibley J, Deed R, Jasiok M, Douglas K, Norton J. A homology model of the Id-3 helix-loop-helix domain as a basis for structure-function predictions. Biochim. Biophys. Acta. 1996, 1294 (2): 138–46. PMID 8645731. doi:10.1016/0167-4838(96)00008-8.
• Loveys DA, Streiff MB, Kato GJ. E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res. 1996, 24 (14): 2813–20. PMC 145994 . PMID 8759016. doi:10.1093/nar/24.14.2813.
• Deed RW, Armitage S, Norton JD. Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism. J. Biol. Chem. 1996, 271 (39): 23603–6. PMID 8798572. doi:10.1074/jbc.271.39.23603.
• Deed RW, Jasiok M, Norton JD. Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism. FEBS Lett. 1996, 393 (1): 113–6. PMID 8804437. doi:10.1016/0014-5793(96)00868-X.
• Chen B, Lim RW. Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression. J. Biol. Chem. 1997, 272 (4): 2459–63. PMID 8999959. doi:10.1074/jbc.272.4.2459.
• Langlands K, Yin X, Anand G, Prochownik EV. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J. Biol. Chem. 1997, 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.
• Deed RW, Hara E, Atherton GT, Peters G, Norton JD. Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol. Cell. Biol. 1997, 17 (12): 6815–21. PMC 232537 . PMID 9372912.
• Deed RW, Jasiok M, Norton JD. Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells. J. Biol. Chem. 1998, 273 (14): 8278–86. PMID 9525934. doi:10.1074/jbc.273.14.8278.
• Asp J, Thornemo M, Inerot S, Lindahl A. The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes. FEBS Lett. 1998, 438 (1-2): 85–90. PMID 9821964. doi:10.1016/S0014-5793(98)01268-X.
• Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J. 1999, 18 (4): 968–76. PMC 1171189 . PMID 10022839. doi:10.1093/emboj/18.4.968.
• Moldes M, Boizard M, Liepvre XL, Fève B, Dugail I, Pairault J. Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes. Biochem. J. 344. 1999,. 344 Pt 3: 873–80. PMC 1220711 . PMID 10585876. doi:10.1042/0264-6021:3440873.
• Bounpheng MA, Dimas JJ, Dodds SG, Christy BA. Degradation of Id proteins by the ubiquitin-proteasome pathway. FASEB J. 1999, 13 (15): 2257–64. PMID 10593873.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y. Protein-protein interaction panel using mouse full-length cDNAs. Genome Res. 2001, 11 (10): 1758–65. PMC 311163 . PMID 11591653. doi:10.1101/gr.180101.
• Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J. Biol. Chem. 2002, 277 (11): 9118–26. PMID 11756408. doi:10.1074/jbc.M107713200.

外部链接

• 医学主题词表（MeSH）：ID3+protein,+human

ID3 (基因)引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。