CTLA-4

CTLA4又称CTLA-4（细胞毒性T淋巴细胞相关抗原4，cytotoxic T-lymphocyte-associated protein 4）或CD152（分化群152），是一种蛋白质受体^[7]。CTLA-4蛋白由小鼠的Ctla4^[8]和人类的CTLA4基因编码^[9]。CTLA-4于1991年首次被发现^[10]。

细胞毒性T淋巴细胞相关抗原4
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 3OSK、​1AH1、​1H6E、​1I85、​1I8L、​2X44、​3BX7
识别号
别名	CTLA4；, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
外部ID	OMIM：123890 MGI：88556 HomoloGene：3820 GeneCards：CTLA4
相关疾病
类风湿性关节炎、​甲状腺机能低下症、​1型糖尿病、​type 1 diabetes mellitus 12、​autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency[1]
为以下药物的标靶
伊匹单抗[2]
基因位置（人类） 染色体 2号染色体[3] 基因座 2q33.2 起始 203,853,888 bp[3] 终止 203,873,965 bp[3]
基因位置（小鼠） 染色体 小鼠1号染色体[4] 基因座 1 C2|1 30.58 cM 起始 60,926,159 bp[4] 终止 60,954,991 bp[4]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • 血浆蛋白结合 细胞组分 • 细胞质的核周区域 • integral component of membrane • clathrin-coated endocytic vesicle • 细胞膜 • 高尔基体 • 膜 • external side of plasma membrane • protein complex involved in cell adhesion • integral component of plasma membrane 生物学过程 • B cell receptor signaling pathway • T cell costimulation • negative regulation of B cell proliferation • 适应性免疫 • negative regulation of regulatory T cell differentiation • 免疫反应 • cellular response to DNA damage stimulus • immune system process • positive regulation of apoptotic process • negative regulation of immune response • negative regulation of T cell proliferation • regulation of regulatory T cell differentiation • regulation of T cell proliferation • T cell receptor signaling pathway Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	1493	12477
Ensembl	ENSG00000163599	ENSMUSG00000026011
UniProt	P16410	P09793
mRNA​序列	NM_001037631 ​NM_005214	NM_001281976 ​NM_009843
蛋白序列	NP_001032720 ​NP_005205	NP_001268905 ​NP_033973
基因位置​（UCSC）	Chr 2: 203.85 – 203.87 Mb	Chr 1: 60.93 – 60.95 Mb
PubMed​查找	[5]	[6]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. 與細胞毒性T淋巴細胞相關抗原4相關的疾病；在維基數據上查看/編輯參考.
2. 對細胞毒性T淋巴細胞相關抗原4起作用的藥物；在維基數據上查看/編輯參考.
3. GRCh38: Ensembl release 89: ENSG00000163599 - Ensembl, May 2017
4. GRCm38: Ensembl release 89: ENSMUSG00000026011 - Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. De-novo and acquired resistance to immune checkpoint targeting. The Lancet. Oncology. December 2017, 18 (12): e731–e741. PMID 29208439. doi:10.1016/s1470-2045(17)30607-1.
8. A new member of the immunoglobulin superfamily--CTLA-4. Nature. 1987, 328 (6127): 267–70. Bibcode:1987Natur.328..267B. PMID 3496540. doi:10.1038/328267a0.
9. Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. European Journal of Immunology. December 1988, 18 (12): 1901–5. PMID 3220103. doi:10.1002/eji.1830181206.
10. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. November 1995, 270 (5238): 985–8. Bibcode:1995Sci...270..985W. JSTOR 2888113. PMID 7481803. doi:10.1126/science.270.5238.985.