2-羟基-5-(4-三氟甲基四氟苄氨基)苯甲酸

2-羟基-5-(4-三氟甲基四氟苄氨基)苯甲酸
法律规范状态
法律规范	Investigational;
识别信息
	IUPAC命名法 2-Hydroxy-5-[[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]methylamino]benzoic acid; ;
CAS号	640290-67-1
PubChem CID	9951955;
化学信息
化学式	C15H8F7NO3
摩尔质量	383.22 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O=C(O)C1=CC(=CC=C1O)NCC2=C(F)C(F)=C(C(F)=C2F)C(F)(F)F;

2-羟基-5-(4-三氟甲基四氟苄氨基)苯甲酸（商品名：Nelonemdaz）是一种实验性药物，用作自由基削减剂和GRIN2B（英语：GRIN2B）的选择性拮抗剂。据推测，它对最近经历过中风的人具有神经保护作用。^[1]^[2]^[3]^[4]

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它可以4-三氟甲基四氟苄溴和5-氨基-2-羟基苯甲酸为原料反应制得。^[5]

参考文献

[1]
Xu, Xiumei; Chen, Mingyu; Zhu, Dongya. Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical. Stroke and Vascular Neurology. 13 October 2023: svn–2023–002671. doi:10.1136/svn-2023-002671 .
[2]
Lee, Jin Soo; Lee, Ji Sung; Gwag, Byoung Joo; Choi, Dennis W; An, Chun San; Kang, Hyun Goo; Song, Tae-Jin; Ahn, Seong Hwan; Kim, Chang Hun; Kwon, Sun U. Abstract TP15: Rationale And Ongoing Status In A Phase 3 Trial Of Nelonemdaz, A Novel Neuroprotection Drug, For Patients With Acute Ischemic Stroke And Reperfusion. Stroke. February 2023, 54 (Suppl_1). doi:10.1161/str.54.suppl_1.TP15.
[3]
Lee, Jin Soo; Lee, Ji Sung; Gwag, Byoung Joo; Choi, Dennis W.; An, Chun San; Kang, Hyun Goo; Song, Tae-Jin; Ahn, Seong Hwan; Kim, Chang Hun; Shin, Dong-Ick; Kwon, Sun U. The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz (RODIN) Trial: Protocol for a Double-Blinded Clinical Trial of Nelonemdaz in Patients with Hyperacute Ischemic Stroke and Endovascular Thrombectomy. Journal of Stroke. 31 January 2023, 25 (1): 160–168. doi:10.5853/jos.2022.02453 .
[4]
Hong, Ji Man; Lee, Jin Soo; Lee, Yeong-Bae; Shin, Dong Hoon; Shin, Dong-Ick; Hwang, Yang-Ha; Ahn, Seong Hwan; Kim, Jae Guk; Sohn, Sung-Il; Kwon, Sun U.; Lee, Ji Sung; Gwag, Byoung Joo; Chamorro, Ángel; Choi, Dennis W.; Chammorro, Ángel; Kim, Eung Yeop; Choi, Jin Wook; Yeo, Min-Ju; Kwak, Jaehyuk; Lee, Sung Eun; Hong, Jeong-Ho; Lee, Sangkil; Lee, Yoon-Joo; Lee, Min-Joo. Nelonemdaz for Patients With Acute Ischemic Stroke Undergoing Endovascular Reperfusion Therapy: A Randomized Phase II Trial. Stroke. November 2022, 53 (11): 3250–3259. doi:10.1161/STROKEAHA.122.039649 .
[5]
Gwag, Byoung Joo; Yoon, Sung Hwa; Moon, Ho Sang; Park, Eun Chan; Won, Seok Joon; Lee, Young Ae; Lee, Hae Un. Preparation of tetrafluorobenzyl derivatives and pharmaceutical composition for treatment of neurodegenerative diseases in the central nervous system. 2003. WO2004000786.

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[1] [1]
Xu, Xiumei; Chen, Mingyu; Zhu, Dongya. Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical. Stroke and Vascular Neurology. 13 October 2023: svn–2023–002671. doi:10.1136/svn-2023-002671 .

[2] [2]
Lee, Jin Soo; Lee, Ji Sung; Gwag, Byoung Joo; Choi, Dennis W; An, Chun San; Kang, Hyun Goo; Song, Tae-Jin; Ahn, Seong Hwan; Kim, Chang Hun; Kwon, Sun U. Abstract TP15: Rationale And Ongoing Status In A Phase 3 Trial Of Nelonemdaz, A Novel Neuroprotection Drug, For Patients With Acute Ischemic Stroke And Reperfusion. Stroke. February 2023, 54 (Suppl_1). doi:10.1161/str.54.suppl_1.TP15.

[3] [3]
Lee, Jin Soo; Lee, Ji Sung; Gwag, Byoung Joo; Choi, Dennis W.; An, Chun San; Kang, Hyun Goo; Song, Tae-Jin; Ahn, Seong Hwan; Kim, Chang Hun; Shin, Dong-Ick; Kwon, Sun U. The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz (RODIN) Trial: Protocol for a Double-Blinded Clinical Trial of Nelonemdaz in Patients with Hyperacute Ischemic Stroke and Endovascular Thrombectomy. Journal of Stroke. 31 January 2023, 25 (1): 160–168. doi:10.5853/jos.2022.02453 .

[4] [4]
Hong, Ji Man; Lee, Jin Soo; Lee, Yeong-Bae; Shin, Dong Hoon; Shin, Dong-Ick; Hwang, Yang-Ha; Ahn, Seong Hwan; Kim, Jae Guk; Sohn, Sung-Il; Kwon, Sun U.; Lee, Ji Sung; Gwag, Byoung Joo; Chamorro, Ángel; Choi, Dennis W.; Chammorro, Ángel; Kim, Eung Yeop; Choi, Jin Wook; Yeo, Min-Ju; Kwak, Jaehyuk; Lee, Sung Eun; Hong, Jeong-Ho; Lee, Sangkil; Lee, Yoon-Joo; Lee, Min-Joo. Nelonemdaz for Patients With Acute Ischemic Stroke Undergoing Endovascular Reperfusion Therapy: A Randomized Phase II Trial. Stroke. November 2022, 53 (11): 3250–3259. doi:10.1161/STROKEAHA.122.039649 .

[5] [5]
Gwag, Byoung Joo; Yoon, Sung Hwa; Moon, Ho Sang; Park, Eun Chan; Won, Seok Joon; Lee, Young Ae; Lee, Hae Un. Preparation of tetrafluorobenzyl derivatives and pharmaceutical composition for treatment of neurodegenerative diseases in the central nervous system. 2003. WO2004000786.

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