胱天蛋白酶7

胱天蛋白酶7
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1F1J、1GQF、1I4O、1I51、1K86、1K88、1KMC、1SHJ、1SHL、2QL5、2QL7、2QL9、2QLB、2QLF、2QLJ、3EDR、3H1P、3IBC、3IBF、3R5K、4FDL、4FEA、4HQ0、4HQR、4JB8、4JJ8、4JR1、4JR2、4LSZ、4ZVR、4ZVQ、4ZVO、4ZVU、4ZVT、4ZVS、4ZVP、5IC6
识别号
别名	CASP7；, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3, Caspase 7
外部ID	OMIM：601761 MGI：109383 HomoloGene：11168 GeneCards：CASP7
相关疾病
	白癜风
为以下药物的标靶
	emricasan
基因位置（人类）
染色体	10号染色体
终止	113,730,907 bp
基因位置（小鼠）
染色体	小鼠19号染色体
终止	56,430,776 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 半胱氨酸型肽酶活性; • cysteine-type endopeptidase activity; • 血浆蛋白结合; • 水解酶活性; • 肽酶活性; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • cysteine-type endopeptidase activity involved in apoptotic process;
细胞组分	• 细胞质; • 细胞质基质; • 细胞核; • 核质;
生物学过程	• 蛋白酶解; • cellular response to staurosporine; • execution phase of apoptosis; • 细胞凋亡;
	Sources:Amigo / QuickGO
直系同源
	840
	12369
	ENSG00000165806
	ENSMUSG00000025076
	P55210
	P97864
NM_001227; NM_001267056; NM_001267057; NM_001267058; NM_033338;
	NM_033339; NM_033340; NM_001320911
	NM_007611
NP_001218; NP_001253985; NP_001253986; NP_001253987; NP_001307840;
	NP_203124; NP_203125; NP_203126
	NP_031637
	维基数据
查看/编辑人类	查看/编辑小鼠

胱天蛋白酶7（英语：Caspase 7）是人类中由CASP7基因编码的一种酶。该酶是一种参与细胞凋亡的半胱氨酸蛋白酶。几乎所有可获得完整基因组数据的哺乳动物中都已鉴定出CASP7直向同源物。^[7]鸟类、蜥蜴、滑体动物和真骨类中也存在独特的直系同源物。

Quick Facts 胱天蛋白酶7, 已知的结构 ...

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作用

胱天蛋白酶7是胱天蛋白酶家族的成员，已被证明是细胞凋亡的执行蛋白。胱天蛋白酶的连续激活在细胞凋亡的执行阶段发挥着核心作用。胱天蛋白酶作为无活性酶原存在，由上游的胱天蛋白酶（胱天蛋白酶8、9）在保守的天冬氨酸残基处经历蛋白水解加工，产生一大一小两个亚基，然后二聚化形成异四聚体形式的活性酶。该酶的前体被胱天蛋白酶3、10和9裂解。该酶在细胞死亡刺激下被激活并诱导细胞凋亡。该基因的选择性剪接产生四种转录变体，编码三种不同的亚型。^[8]

相互作用

胱天蛋白酶7已被证明可以与以下物质相互作用：

胱天蛋白酶8^[9]^[10]
存活素^[11]^[12]
X连锁凋亡抑制蛋白^[13]^[14]^[15]^[16]

参见

蛋白酶解图谱
胱天蛋白酶

参考文献

[1]
與胱天蛋白酶7相關的疾病；在維基數據上查看/編輯參考.
[2]
對Caspase 7起作用的藥物；在維基數據上查看/編輯參考.
[3]
GRCh38: Ensembl release 89: ENSG00000165806 - Ensembl, May 2017
[4]
GRCm38: Ensembl release 89: ENSMUSG00000025076 - Ensembl, May 2017
[5]
Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
[6]
Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
[7]
OrthoMaM phylogenetic marker: CASP7 coding sequence. [2009-12-20]. （原始内容存档于2016-03-04）.
[8]
Entrez Gene: CASP7 caspase 7, apoptosis-related cysteine peptidase.
[9]
Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. Apr 2002, 277 (16): 13430–7. PMID 11832478. doi:10.1074/jbc.M108029200 .
[10]
Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri ES. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. Dec 1996, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. PMC 26159 . PMID 8962078. doi:10.1073/pnas.93.25.14486 .
[11]
Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. Dec 1998, 58 (23): 5315–20. PMID 9850056.
[12]
Shin S, Sung BJ, Cho YS, Kim HJ, Ha NC, Hwang JI, Chung CW, Jung YK, Oh BH. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry. Jan 2001, 40 (4): 1117–23. PMID 11170436. doi:10.1021/bi001603q.
[13]
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS. Structural basis for the inhibition of caspase-3 by XIAP. Cell. Mar 2001, 104 (5): 791–800. PMID 11257232. S2CID 17915093. doi:10.1016/S0092-8674(01)00274-4 .
[14]
Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. Dec 1997, 16 (23): 6914–25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.
[15]
Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. Jul 1997, 388 (6639): 300–4. Bibcode:1997Natur.388..300D. PMID 9230442. S2CID 4395885. doi:10.1038/40901 .
[16]
Suzuki Y, Nakabayashi Y, Nakata K, Reed JC, Takahashi R. X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. J. Biol. Chem. Jul 2001, 276 (29): 27058–63. PMID 11359776. doi:10.1074/jbc.M102415200 .

拓展阅读

Cohen GM. Caspases: the executioners of apoptosis. Biochem. J. 1997, 326 (Pt 1): 1–16. PMC 1218630 . PMID 9337844. doi:10.1042/bj3260001.

外部链接

肽酶及其抑制剂的MEROPS在线数据库：C14.004^{[失效链接]}
PDB中UniProt可用的所有结构信息之概述：P55210 (Human Caspase-7) 在PDBe-KB（英语：PDBe-KB）。

[1] [1]
與胱天蛋白酶7相關的疾病；在維基數據上查看/編輯參考.

[2] [2]
對Caspase 7起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] [3]
GRCh38: Ensembl release 89: ENSG00000165806 - Ensembl, May 2017

[refGRCm38Ensembl-4] [4]
GRCm38: Ensembl release 89: ENSMUSG00000025076 - Ensembl, May 2017

[5] [5]
Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] [6]
Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[OrthoMaM-7] [7]
OrthoMaM phylogenetic marker: CASP7 coding sequence. [2009-12-20]. （原始内容存档于2016-03-04）.

[8] [8]
Entrez Gene: CASP7 caspase 7, apoptosis-related cysteine peptidase.

[pmid11832478-9] [9]
Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. Apr 2002, 277 (16): 13430–7. PMID 11832478. doi:10.1074/jbc.M108029200 .

[pmid8962078-10] [10]
Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri ES. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. Dec 1996, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. PMC 26159 . PMID 8962078. doi:10.1073/pnas.93.25.14486 .

[pmid9850056-11] [11]
Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. Dec 1998, 58 (23): 5315–20. PMID 9850056.

[pmid11170436-12] [12]
Shin S, Sung BJ, Cho YS, Kim HJ, Ha NC, Hwang JI, Chung CW, Jung YK, Oh BH. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry. Jan 2001, 40 (4): 1117–23. PMID 11170436. doi:10.1021/bi001603q.

[pmid11257232-13] [13]
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS. Structural basis for the inhibition of caspase-3 by XIAP. Cell. Mar 2001, 104 (5): 791–800. PMID 11257232. S2CID 17915093. doi:10.1016/S0092-8674(01)00274-4 .

[pmid9384571-14] [14]
Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. Dec 1997, 16 (23): 6914–25. PMC 1170295 . PMID 9384571. doi:10.1093/emboj/16.23.6914.

[pmid9230442-15] [15]
Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. Jul 1997, 388 (6639): 300–4. Bibcode:1997Natur.388..300D. PMID 9230442. S2CID 4395885. doi:10.1038/40901 .

[pmid11359776-16] [16]
Suzuki Y, Nakabayashi Y, Nakata K, Reed JC, Takahashi R. X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. J. Biol. Chem. Jul 2001, 276 (29): 27058–63. PMID 11359776. doi:10.1074/jbc.M102415200 .

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