甲磺酸酯

甲磺酸酯（mesylate）在化学上是指所有的"甲磺酸"（CH₃SO₃H）和醇或醇的类似物形成的衍生物。当辩证医药品所含有的基(官能团和自由基)或"阴离子"(anion)之国际非专利药品名称时，甲磺酸酯(mesylate)正确的拼写是甲磺酸(mesilate，"甲磺酸伊马替尼"(imatinib mesilate)、又为"伊马替尼甲磺酸")。^[1]

甲磺酸酯是有机化合物的基(团)且共享著一般的结构CH₃SO₂O−R(简称MsO−R)的普通官能团，其中R是一种"有机取代物"(organic substituent)。甲磺酸酯在亲核取代反应上被认为是一种极佳的离去基团。

"甲磺酰基"(mesyl)是"甲磺酸酯"(methanesulfonyl)或CH₃SO₂−(Ms−)官能团的术语。比如，甲基磺酰氯通常被称为"甲磺酰氯"(mesyl chloride)。

甲磺酸酯在具有盐基(通常为胺盐基、如三乙胺)的情况下可使用醇及与甲基磺酰氯进行制备。^[2]

甲磺酸酯可使用醇、甲磺酸酐(Methanesulfonic anhydride)及盐基的复合情况下进行制备，虽然这种方法通常用于仅当考虑"氯亲核性"的情况才使用。

[1]
World Health Organization. International Nonproprietary Names Modified (PDF). INN Working Document 05.167/3. WHO. February 2006 [2014-03-16]. （原始内容存档 (PDF)于2013-10-26）. Retrieved 5 December 2008.
[2]
Rick L. Danheiser, Yeun-Min Tsai, and David M. Fink (1993). "A General Method for the Synthesis of Allenylsilanes: 1-Methyl-1-(trimethylsilyl)allene". Org. Synth.; Coll. Vol. 8: 471. (a procedure illustrating the use of mesylates)

[1] [1]
World Health Organization. International Nonproprietary Names Modified (PDF). INN Working Document 05.167/3. WHO. February 2006 [2014-03-16]. （原始内容存档 (PDF)于2013-10-26）. Retrieved 5 December 2008.

[2] [2]
Rick L. Danheiser, Yeun-Min Tsai, and David M. Fink (1993). "A General Method for the Synthesis of Allenylsilanes: 1-Methyl-1-(trimethylsilyl)allene". Org. Synth.; Coll. Vol. 8: 471. (a procedure illustrating the use of mesylates)

[1]

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甲磺酸酯

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制备

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