王开化(?—1861年),字梅村,为王錱族弟,十七岁时随王錱征战。王錱殁后,王开化与张运兰共领王錱旧部,之后王开化辞官至城南书院讲学。王开化与左宗棠往来甚切,并交为好友;[1]。1860年左宗棠组建楚军并收编王錱旧部,王开化受命负责营务工作。1861年左宗棠攻打浙江太平军前夕,王开化因病辞官,不久病逝。[2][3][4]

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